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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

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Changes in Bladder Volume During Radiotherapy for Prostate Cancer.

Dirk Rades^1,2, Florian Cremers², Christian Ziemann²

¹Department of Radiation Oncology, University of Lübeck, Lübeck, Germany; dirk.rades@uksh.de.

Anticancer Research

|September 30, 2024

Summary

Many prostate cancer patients had small bladder volumes during radiation therapy, increasing urinary toxicity risk. Pre-treatment bladder volume and cancer risk were key factors, informing future mobile app interventions.

Keywords:

Prostate cancer bladder volume radiotherapy course risk factors

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Area of Science:

Radiation Oncology
Urology
Medical Physics

Background:

Prostate cancer radiotherapy can cause urinary toxicity, exacerbated by small bladder volumes.
A mobile app intervention is proposed to help patients maintain adequate bladder volume.
This study assesses bladder volumes during radiotherapy to inform future app-based trials.

Purpose of the Study:

To evaluate the frequency of small bladder volumes (<200 ml) during prostate cancer radiotherapy.
To identify risk factors associated with reduced bladder volumes.
To provide data for designing a prospective trial of a bladder volume reminder app.

Main Methods:

Retrospective analysis of 72 patients undergoing external beam radiotherapy for non-metastatic prostate cancer.
Evaluation of bladder volumes (<200 ml) per fraction.
Statistical analysis of seven potential risk factors, including pre-radiotherapy bladder volume and cancer risk level.

Main Results:

A high number of radiation fractions (mean 17.8) had bladder volumes <200 ml.
Pre-radiotherapy bladder volumes <200 ml were significantly associated with more fractions with small volumes (p<0.001).
High-risk prostate cancer was also significantly associated with smaller bladder volumes during treatment (p=0.014).

Conclusions:

The high incidence of small bladder volumes during prostate cancer radiotherapy necessitates intervention.
Pre-treatment bladder volume and prostate cancer risk level are critical factors influencing bladder volume during treatment.
Findings support the design of a prospective trial for a bladder volume management mobile application.