Best Practices in Treatment of Fungal Urinary Tract Infections

Reid A Stubbee1, Joanna Orzel1, Chad R Tracy1

  • 1Department of Urology, University of Iowa Hospitals and Clinics, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52245, USA.

PubMed

Insights

Fungal urinary tract infections (candiduria) are common in hospitalized patients, especially those with catheters or diabetes. While often asymptomatic, candiduria can become severe, requiring review of its causes, diagnosis, and treatments.

Area of Science:

  • Urology
  • Infectious Diseases
  • Mycology

Background:

  • Fungal pathogens, particularly Candida species, are frequently detected in the urine of hospitalized individuals.
  • Candiduria (fungal presence in urine) is associated with specific patient populations including those with urinary drainage devices, post-surgical status, urologic instrumentation, and diabetes mellitus.

Purpose of the Study:

  • To comprehensively review the epidemiology and risk factors contributing to fungal urinary tract infections.
  • To discuss the diagnostic approaches and classification of candiduria.
  • To provide an overview of current therapeutic strategies, encompassing both medical and surgical interventions.

Main Methods:

  • Literature review of epidemiological data on fungal urinary tract infections.
  • Analysis of risk factors associated with candiduria development.
  • Synthesis of current diagnostic criteria and treatment guidelines for fungal UTIs.

Main Results:

  • Candiduria is prevalent in specific hospitalized patient groups.
  • Risk factors include indwelling urinary devices, surgery, urologic procedures, and diabetes.
  • The clinical presentation ranges from asymptomatic to life-threatening.

Conclusions:

  • Understanding the epidemiology and risk factors is crucial for managing candiduria.
  • Accurate diagnosis and categorization guide appropriate treatment selection.
  • Current medical and surgical treatments offer various options for addressing fungal UTIs.

Related Concept Videos

Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care01:30

Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care

A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
2
Urinary Tract Infection IV: Nursing Management01:17

Urinary Tract Infection IV: Nursing Management

In managing urinary tract infections (UTIs) in nursing, a comprehensive assessment is essential. Begin by gathering subjective data, such as the patient’s complaints of dysuria (painful urination), urinary frequency, urgency, suprapubic pain, and any lower abdominal discomfort. This information can be complemented by questions regarding previous UTIs, sexual activity, and personal hygiene practices, which can provide insight into risk factors. Objective assessment should focus on signs...
2
Urinary Tract Infection I: Introduction01:26

Urinary Tract Infection I: Introduction

Urinary tract infections (UTIs) impact various parts of the urinary system, including the kidneys, ureters, bladder, and urethra. These infections are generally bacterial, with Escherichia coli being the most common causative agent, often originating from the gastrointestinal tract. However, other bacteria, such as Staphylococcus saprophyticus, Klebsiella pneumoniae, and Proteus mirabilis, are also known to cause UTIs. The type, location, and underlying complexity of the UTI guide both...
2
Urine Studies II: Urine Culture and Sensitivity Test01:26

Urine Studies II: Urine Culture and Sensitivity Test

A urine culture and sensitivity test is a diagnostic procedure used to identify urinary tract bacterial infections and determine the most effective antibiotics for treatment. This test is generally preferred when a patient shows manifestations of a urinary tract infection, such as frequent or painful urination, cloudy or foul-smelling urine, or lower abdominal pain.Purpose of the TestThe primary goals of a urine culture and sensitivity test are to:Determine the specific bacteria causing the...
3
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
2
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
2