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Updated: Jun 11, 2025

Isolation and Characterization of Microvesicles from Peripheral Blood
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Isolation and Characterization of Microvesicles from Peripheral Blood

Published on: January 6, 2017

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Pathogenic mechanisms, diagnostic, and therapeutic potential of microvesicles in diabetes and its complications

Alaa Abbas1, Heba Almaghrbi1, Roberta Giordo2

  • 1Department of Biomedical Science, College of Health Sciences, Member of QU Health, Qatar University, P.O. Box 2713, Doha, Qatar.

Archives of Biochemistry and Biophysics
|September 30, 2024
PubMed

Insights

Microvesicles (MVs) are key in diabetes and its complications, mediating cell communication. Research explores MVs

Area of Science:

  • Biomedical Sciences
  • Cell Biology
  • Endocrinology

Background:

  • Extracellular vesicles (EVs), especially microvesicles (MVs), are crucial for intercellular communication.
  • Their roles in physiological and pathological states, including diabetes mellitus (DM) and its complications, are increasingly recognized.

Purpose of the Study:

  • To comprehensively review the emerging roles of MVs in the pathogenesis of diabetes and its complications.
  • To examine the molecular mechanisms and potential clinical applications of MVs in diabetes.

Main Methods:

  • Literature review focusing on MVs in diabetes pathogenesis.
  • Analysis of MVs' cargo (proteins, lipids, nucleic acids) and their regulatory functions.
  • Discussion of current challenges and future directions in MV research.

Main Results:

  • MVs contribute to diabetes complications like nephropathy, retinopathy, cardiomyopathy, and neuropathy.
  • MV cargo regulates inflammation, oxidative stress, immune responses, and tissue remodeling, driving disease progression.
  • MVs show potential as biomarkers for diagnosis and as drug delivery vehicles.

Conclusions:

  • MVs play a significant role in the pathogenesis of diabetes and its complications.
  • Further research is needed to overcome challenges in MV isolation, characterization, and clinical validation.
  • Advanced techniques and improved methods are essential for translating MVs into clinical applications for improved diabetes patient outcomes.
Keywords:
BiomarkersDiabetesDiabetes complicationsMicrovesiclesPathogenesisTherapeutic potential

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