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The Psychometric Performance of the Kansas City Cardiomyopathy Questionnaire-12 in Symptomatic Obstructive

Andrew J Sauer1, Charles F Sherrod1, Kensey L Gosch1

  • 1University of Missouri Kansas City's Healthcare Institute for Innovations in Quality and Saint Luke's Mid America Heart Institute, Kansas City, Missouri, USA.

Journal of Cardiac Failure
|September 30, 2024
PubMed

Insights

The 12-item Kansas City Cardiomyopathy Questionnaire (KCCQ-12) shows strong psychometric performance in obstructive hypertrophic cardiomyopathy (oHCM) patients. This validated tool is comparable to the KCCQ-23, supporting its use in clinical practice.

Area of Science:

  • Cardiology
  • Patient-Reported Outcomes
  • Clinical Assessment

Background:

  • Improving symptoms, function, and quality of life is key in obstructive hypertrophic cardiomyopathy (oHCM) care.
  • The 23-item Kansas City Cardiomyopathy Questionnaire (KCCQ-23) has established psychometric properties in oHCM.
  • The shorter 12-item KCCQ-12 is increasingly used but requires psychometric validation in oHCM.

Purpose of the Study:

  • To evaluate the psychometric properties of the KCCQ-12 in patients with oHCM.
  • To determine if the KCCQ-12 is a reliable and valid measure for assessing oHCM patients.

Main Methods:

  • Analysis of data from the EXPLORER-HCM clinical trial.
  • Assessment of KCCQ-12 domain and summary scores against clinical and patient-reported measures.
  • Evaluation of internal consistency, test-retest reliability, and responsiveness to clinical change.

Main Results:

  • KCCQ-12 scores showed moderate correlations with key clinical (NYHA class, exercise duration, VO2 max) and patient-reported outcomes (EQ-5D-5L, WPAI, HCMSQ).
  • Strong internal consistency and test-retest reliability were observed for KCCQ-12 domain scores.
  • The KCCQ-12 demonstrated significant and proportional changes with clinical improvements and showed close equivalence to KCCQ-23 scores.

Conclusions:

  • The KCCQ-12 exhibits good psychometric performance in patients with oHCM.
  • Its performance is comparable to the KCCQ-23.
  • The KCCQ-12 is a suitable tool for use in clinical practice for managing oHCM patients.
Abstract

Keywords:
Hypertrophic cardiomyopathyKansas City Cardiomyopathy Questionnairepatient-reported outcomespsychometric properties

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