Related Experiment Video
Updated: Jun 11, 2025
![Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F60445.jpg&w=3840&q=50)
04:12
Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA
Published on: December 19, 2019
14.2K
COVID-19 and Carcinogenesis: Exploring the Hidden Links
Özgür Tanrıverdi1, Ali Alkan1, Turan Karaoglu2
1Medical Oncology, Muğla Sıtkı Koçman University Faculty of Medicine, Muğla, TUR.
Cureus
|October 1, 2024
Summary
The SARS-CoV-2 virus, causing COVID-19, may increase cancer risk through immune changes and inflammation. Increased cancer surveillance is crucial for COVID-19 survivors due to potential long-term carcinogenic effects.
Area of Science:
- Oncology
- Virology
- Immunology
Background:
- The COVID-19 pandemic's immediate effects are well-documented, but long-term consequences, including cancer development, are emerging.
- SARS-CoV-2 infection may influence carcinogenesis through various biological pathways.
Purpose of the Study:
- To comprehensively review the complex relationship between COVID-19 and cancer development.
- To explore molecular mechanisms, therapeutic impacts, and co-infection interactions in COVID-19-associated carcinogenesis.
Main Methods:
- Literature review focusing on immune dysregulation, chronic inflammation, and genetic/epigenetic alterations.
- Analysis of molecular mechanisms involving ACE2, TMPRSS2, and FURIN in cancer progression.
- Examination of long-term treatment effects and co-infection interactions.
Main Results:
- COVID-19 may promote cancer via immune dysregulation, chronic inflammation (e.g., interleukin-6), and genetic/epigenetic changes.
- Molecular pathways involving ACE2, TMPRSS2, and FURIN are implicated in SARS-CoV-2's role in cancer progression.
- Co-infections with oncogenic viruses and long-term treatments may also influence cancer risk.
Conclusions:
- Increased cancer surveillance in COVID-19 survivors is recommended.
- Further research is needed to elucidate the precise mechanisms linking COVID-19 to cancer development and progression.
Related Concept Videos
02:59Cancer Prevention
6.1K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.1K
01:25Mutagenicity and Carcinogenicity
1.2K
Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
1.2K
01:33Cancer-Critical Genes I: Proto-oncogenes
8.7K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
8.7K
01:51Mechanisms of Retrovirus-induced Cancers
5.1K
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
5.1K
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
7.3K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
7.3K
02:18Cancer
48.1K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
48.1K