Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Types of Toxins

Types of Toxins

Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...

The Periodic Table and Organismal Elements

The Periodic Table and Organismal Elements

Prevention of Further Absorption of Poison

Prevention of Further Absorption of Poison

In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...

Toxic Reactions: Overview

Toxic Reactions: Overview

When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...

Anticholinesterase Agents: Poisoning and Treatment

Anticholinesterase Agents: Poisoning and Treatment

Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...

Minerals

Minerals

Minerals are essential nutrients that the human body needs in small amounts to work properly. They play a vital role in many bodily functions, such as building strong bones and transmitting nerve impulses. Some minerals are needed for hormone production or to maintain a normal heartbeat. Major minerals include calcium, phosphorus, potassium, sulfur, sodium, chlorine, and magnesium, while trace minerals include iron, manganese, copper, iodine, zinc, cobalt, fluoride, and selenium.

Major...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The Intersection of Climate and Equity in Clinical Pediatric Practice.

Pediatric clinics of North America·2026

Same author

Climate-Related Health Impacts and Mitigation Strategies in Clinical Settings.

Pediatric clinics of North America·2026

Same author

Place-Based Inequities in E-Cigarette/Vape and Cannabis Retail Density in Massachusetts: The Role of Child Opportunity and Social Vulnerability.

Chest·2026

Same author

Predicting asthma prevalence across US communities by integrating social vulnerability and environmental risk with machine learning.

The Journal of allergy and clinical immunology·2026

Same author

Disparities in Admissions for RSV: A Retrospective Observational Study.

Pediatric emergency care·2026

Same author

Tenant Reported Triggers Are Associated With Pediatric Asthma Emergency Department Visits.

Academic pediatrics·2026

Search research articles

Related Experiment Video

Updated: Jun 11, 2025

Removal of Trace Elements by Cupric Oxide Nanoparticles from Uranium In Situ Recovery Bleed Water and Its Effect on Cell Viability

Removal of Trace Elements by Cupric Oxide Nanoparticles from Uranium In Situ Recovery Bleed Water and Its Effect on Cell Viability

Published on: June 21, 2015

Lead Toxicity From Imported Jewelry.

Marissa Hauptman^1,2,3, Marc Nascarella⁴, Jocelyn Silvester^1,2

¹Departments of Pediatrics.

|October 1, 2024

Summary

A child

More Related Videos

Author Spotlight: Investigating the Tolerance of Cabbage Butterflies to Urban Pollutants

Author Spotlight: Investigating the Tolerance of Cabbage Butterflies to Urban Pollutants

Published on: August 18, 2023

Use of Autometallography to Localize and Semi-Quantify Silver in Cetacean Tissues

Use of Autometallography to Localize and Semi-Quantify Silver in Cetacean Tissues

Published on: October 4, 2018

Related Experiment Videos

Last Updated: Jun 11, 2025

Removal of Trace Elements by Cupric Oxide Nanoparticles from Uranium In Situ Recovery Bleed Water and Its Effect on Cell Viability

Removal of Trace Elements by Cupric Oxide Nanoparticles from Uranium In Situ Recovery Bleed Water and Its Effect on Cell Viability

Published on: June 21, 2015

Author Spotlight: Investigating the Tolerance of Cabbage Butterflies to Urban Pollutants

Author Spotlight: Investigating the Tolerance of Cabbage Butterflies to Urban Pollutants

Published on: August 18, 2023

Use of Autometallography to Localize and Semi-Quantify Silver in Cetacean Tissues

Use of Autometallography to Localize and Semi-Quantify Silver in Cetacean Tissues

Published on: October 4, 2018

Area of Science:

Pediatric Toxicology
Environmental Health
Materials Science

Background:

Lead poisoning poses a significant risk to children's health.
Ingestion of foreign objects can lead to toxic exposures.
Metallic jewelry is a potential source of lead exposure.

Purpose of the Study:

To report a case of lead poisoning in a child due to ingestion of a lead-containing medallion.
To analyze the composition and bioavailability of the ingested object.
To model the predicted blood lead levels using established pharmacokinetic models.

Main Methods:

X-ray fluorescence spectroscopy and field emission scanning electron microscopy for elemental analysis.
Simulated gastric extraction to estimate oral bioavailability.
US Environmental Protection Agency Integrated Exposure Uptake Biokinetic (IEUBK) model for blood lead level prediction.

Main Results:

The medallion's composition was 15% lead, 53% copper, and other elements.
Estimated ingestion of 7786 µg/day with 50% bioavailability.
IEUBK modeling predicted blood lead levels to rise from 2.05 µg/dL to 173.9 µg/dL.
The medallion contained 550 times the allowable lead content for children's jewelry.

Conclusions:

Ingested metallic jewelry can cause severe, life-threatening lead poisoning in children.
Novel sources of lead exposure, like imported jewelry, pose a global environmental health risk.
Strict regulation and awareness are crucial to prevent pediatric lead exposure from consumer products.