Inflammation and aging-related disease: A transdisciplinary inflammaging framework.
Brian J Andonian1, Joseph A Hippensteel2, Katrina Abuabara3
1Division of Rheumatology and Immunology, Duke University School of Medicine, Durham, NC, USA. brian.andonian@duke.edu.
Geroscience
|October 1, 2024
Summary
Inflammaging, chronic inflammation in aging, drives frailty and disease. A transdisciplinary approach is proposed to improve understanding and treatment for better care in older adults.
Area of Science:
- Gerontology and Immunology
- Clinical Medicine
Background:
- Inflammaging, a chronic, low-grade inflammation during aging, is linked to adverse outcomes like frailty, disability, and mortality.
- It is a hallmark of aging and contributes to aging-related diseases.
- Anti-inflammatory therapies show promise for anti-aging and treating age-related diseases.
Purpose of the Study:
- To address gaps in defining, measuring, and treating inflammaging in clinical geroscience.
- To advance clinical research and patient-centered care for older adults regarding inflammation.
- To illustrate the impact of inflammaging across aging-related diseases and identify intervention opportunities.
Main Methods:
- Integration of insights from nine medical subspecialties.
- Review of current understanding and clinical trial data on inflammaging and anti-inflammatory therapies.
- Proposal of a transdisciplinary framework for research and clinical practice.
Main Results:
- Inflammaging significantly impacts a wide range of aging-related diseases.
- Numerous opportunities exist for targeted anti-inflammatory interventions.
- A transdisciplinary approach is crucial for comprehensive understanding and treatment.
Conclusions:
- Inflammaging is a critical factor in aging and associated diseases.
- Targeted interventions and a collaborative, transdisciplinary approach can improve care for older adults.
- Further research is needed to fully integrate inflammaging into clinical geroscience.
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