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Non-coding RNAs in meningitis: Key regulators of immune response and inflammation
Mohd Imran1, Abida2, Mehnaz Kamal3
1Department of Pharmaceutical Chemistry, College of Pharmacy, Northern Border University, Rafha 91911, Saudi Arabia; Center for Health Research, Northern Border University, Arar, Saudi Arabia.
Pathology, Research and Practice
|October 1, 2024
Summary
Non-coding RNAs (ncRNAs), including circular RNAs (circRNAs), long non-coding RNAs (lncRNAs), and micro-ribonucleic acids (miRNAs), play key roles in meningitis. These ncRNAs are vital for immune response, diagnosis, and potential therapeutic strategies.
Area of Science:
- Molecular Biology
- Immunology
- Genetics
Background:
- Non-coding RNAs (ncRNAs) encompass circular RNAs (circRNAs), long non-coding RNAs (lncRNAs), and micro-ribonucleic acids (miRNAs).
- These molecules are crucial regulators of gene expression and cellular functions.
- Emerging evidence highlights their significant involvement in the pathophysiology of inflammatory meningitis.
Purpose of the Study:
- To review the intricate roles of ncRNAs in modulating inflammation and immune responses during meningitis.
- To explore the potential of ncRNAs as diagnostic and prognostic biomarkers for meningitis.
- To discuss the therapeutic implications of targeting ncRNAs for meningitis treatment.
Main Methods:
- Literature review of current research on ncRNAs in meningitis.
- Analysis of ncRNA functions in immune cell development, cytokine production, and pathogen recognition.
- Examination of ncRNA expression patterns in disease states and bio-fluids.
Main Results:
- ncRNAs orchestrate host immune responses in meningitis by influencing immune cell development and cytokine production.
- lncRNAs and circRNAs are linked to gene networks governing immune responses.
- miRNAs precisely modulate pro- and anti-inflammatory cytokine expression.
Conclusions:
- ncRNAs are critical players in the immune response during meningitis.
- Their unique expression patterns and stability make them promising biomarkers for meningitis diagnosis and prognosis.
- Targeting ncRNAs presents a potential therapeutic avenue for managing meningitis by modulating immune regulation and inflammation.
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