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The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

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Updated: Jun 11, 2025

A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication

A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication

Published on: September 20, 2016

Mimicking and analyzing the tumor microenvironment.

Roxane Crouigneau¹, Yan-Fang Li², Jamie Auxillos³

¹Section for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.

Cell Reports Methods

|October 1, 2024

Summary

This summary is machine-generated.

The tumor microenvironment (TME) significantly impacts cancer progression and treatment outcomes. Understanding TME complexity requires advanced models and high-resolution analysis tools for effective cancer research.

Keywords:

CP: Biotechnology CP: Cancer biology cancer heterogeneity metabolism microfluidics organoids tumor microenvironment tumor models

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Last Updated: Jun 11, 2025

A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication

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Published on: September 20, 2016

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors

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Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

Published on: April 30, 2021

Area of Science:

Oncology
Cancer Biology
Biomedical Engineering

Background:

The tumor microenvironment (TME) is critical for solid tumor development and therapeutic response.
TME characteristics like hypoxia, acidosis, and heterogeneity influence cancer aggressiveness and resistance.
Complex interactions between cancer cells and their environment drive disease progression.

Purpose of the Study:

To review the advantages and limitations of current models and methods for TME research.
To guide future research directions in understanding the TME.
To outline challenges in analyzing the complex TME.

Main Methods:

Review of existing literature on TME models and analysis tools.
Evaluation of sophisticated cancer models for TME property control and analysis.
Assessment of high-resolution analysis techniques for TME complexity.

Main Results:

The TME's role in cancer development and therapy resistance is multifaceted.
Sophisticated models and high-resolution tools are essential for TME research.
Current models and methods have specific advantages and limitations.

Conclusions:

Further research is needed to fully understand the TME.
Development of advanced models and analytical techniques is crucial.
Addressing TME complexity is key to improving cancer treatment.