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Panniculitis with fever of unknown origin
Dhanushan Gnanendran1, Thamir Alshamari2, Arif Muhammad2
1Peadiatrics, Scarborough General Hospital, Scarborough, North Yorkshire, UK dhanushan.gnanendran1@nhs.net.
BMJ Case Reports
|October 1, 2024
Summary
A child with a rare chromosomal deletion experienced recurrent fevers and panniculitis. Early biopsy and multidisciplinary care are crucial for diagnosing and managing complex pediatric cases of fever of unknown origin (FUO).
Area of Science:
- Pediatric Rheumatology
- Genetics
- Dermatology
Background:
- A young girl presented with a complex medical history including 10q21.2 deletion, hypothyroidism, atrioventricular block, developmental delay, GERD, constipation, and recurrent fevers.
Observation:
- The patient developed subcutaneous nodules indicative of panniculitis, complicating the diagnostic process for fever of unknown origin (FUO).
- Diagnosis was challenging, requiring collaboration among geneticists, dermatologists, rheumatologists, and pediatricians.
Findings:
- Panniculitis and FUO in a pediatric patient with a significant genetic anomaly.
- The case highlights diagnostic difficulties in complex pediatric presentations.
Implications:
- Emphasizes the critical need for comprehensive diagnostic evaluations, including early biopsy of nodular lesions, to rule out malignancy and guide treatment.
- Underscores the importance of continuous multidisciplinary teamwork and close patient monitoring for optimizing outcomes in complicated pediatric cases.
- Contributes to understanding the management of panniculitis and FUO in children, advocating for a holistic treatment approach.
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