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Selenium Improves Arsenic-Induced Male Reproductive Dysfunction by Regulating H3K14ac Level.

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Selenium effectively counteracts arsenic

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Area of Science:

  • Environmental Toxicology
  • Reproductive Biology
  • Epigenetics

Background:

  • Arsenic exposure is linked to male reproductive damage.
  • Understanding arsenic's reproductive toxicity and effective antidotes is crucial.
  • Selenium (Se) is vital for male reproduction and can mitigate environmental toxin effects.

Purpose of the Study:

  • To investigate if selenium can antagonize arsenic-induced male reproductive toxicity.
  • To explore the role of the H3K14ac pathway in selenium's protective effects.
  • To determine the appropriate dosage of selenium for mitigating arsenic toxicity.

Main Methods:

  • Rats were exposed to arsenic and treated with varying doses of selenium.
  • Measurements included arsenic levels in testes, sperm quality, testosterone levels, and steroidogenic gene expression.
  • Analysis of H3K14ac levels and associated enzymes (KAT2A, BAZ2A, HDAC6) was performed.

Main Results:

  • Selenium intervention reduced arsenic accumulation in rat testes, likely by enhancing excretion.
  • Selenium improved testicular injury, sperm quality, and testosterone levels in arsenic-exposed rats.
  • Selenium normalized H3K14ac levels and the expression of KAT2A, BAZ2A, and HDAC6.

Conclusions:

  • Selenium effectively mitigates arsenic-induced male reproductive toxicity.
  • The protective mechanism involves regulating the H3K14ac pathway and enhancing antioxidative capacity.
  • The optimal dose of selenium for mitigating arsenic's male reproductive toxicity is 1 mg/kg.