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Photoprotection and skin coloring by oral carotenoids
Abstract:
A new combination of beta-carotene (25 mg) and canthaxanthin (35 mg) was clinically investigated in 74 patients with various photodermatoses and 111 patients with pigmentation disorders. The photoprotective action of this combination was ascertained in clinical experiments. Serum levels were determined in 20 patients; the absence of increased retinol levels could be confirmed. In 23 patients, ophthalmological controls did not reveal any abnormalities. In 65 of the 74 patients with photodermatoses, a satisfactory protective action was recorded. 85 of the 111 patients with depigmentations and hyperpigmentations experienced a marked decrease of the disturbing contrast between their lesions and the surrounding skin.
Insights
This study found that a combination of beta-carotene and canthaxanthin effectively protected against photodermatoses and improved pigmentation disorders. The treatment showed no adverse effects on serum retinol or ophthalmological health.
Area of Science:
- Dermatology
- Nutritional Science
- Photobiology
Background:
- Photodermatoses and pigmentation disorders significantly impact quality of life.
- Oral carotenoids are known for their antioxidant and photoprotective properties.
Purpose of the Study:
- To evaluate the clinical efficacy and safety of a combined beta-carotene and canthaxanthin formulation.
- To assess the photoprotective effects and impact on skin pigmentation disorders.
Main Methods:
- Clinical investigation of 74 patients with photodermatoses and 111 with pigmentation disorders.
- Determination of serum beta-carotene and retinol levels.
- Ophthalmological examinations to assess safety.
Main Results:
- A satisfactory photoprotective action was observed in 65 of 74 patients with photodermatoses.
- 85 of 111 patients with pigmentation disorders showed a marked decrease in contrast.
- Serum retinol levels did not increase, and no ophthalmological abnormalities were detected.
Conclusions:
- The combination of beta-carotene and canthaxanthin is a safe and effective treatment for photodermatoses.
- This formulation can significantly improve the cosmetic appearance of pigmentation disorders.