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Nanocarriers for Cannabinoid Delivery: Enhancing Therapeutic Potential.
Varun Singh1, Samar Vihal2, Rupali Rana1
1Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, 143005, India.
Recent Advances in Drug Delivery and Formulation
|October 2, 2024
Summary
Nanotechnology offers solutions for medical cannabis delivery challenges. Encapsulating cannabinoids in nanocarriers improves bioavailability, solubility, and targeted distribution for enhanced therapeutic effects.
Area of Science:
- Pharmacology
- Nanotechnology
- Medicinal Chemistry
Background:
- Medical cannabis shows therapeutic potential for pain, anxiety, depression, and neurological disorders.
- Phytocannabinoids are key active compounds, but their complex nature hinders effective medicinal use.
- Challenges include inconsistent bioavailability, poor solubility, and absorption issues with conventional cannabis medicines.
Purpose of the Study:
- To review research and patents on nanotechnology applications for improving medical cannabis delivery.
- To identify how nanocarriers address challenges in bioavailability, solubility, and controlled release of cannabinoids.
- To synthesize findings on nanotechnology's potential to enhance cannabis-based therapies.
Main Methods:
- Comprehensive review of 36 research papers and 19 patents related to cannabis nanotechnology.
- Analysis of studies focusing on nanocarrier encapsulation techniques for cannabinoids.
- Evaluation of reported improvements in bioavailability, release profiles, solubility, and stability.
Main Results:
- 7 out of 36 reviewed papers reported enhanced bioavailability of cannabis compounds.
- Several papers and patents focused on improving drug release, solubility, and stability using nanocarriers.
- 19 analyzed patents detailed effective nanocarrier encapsulation methods for cannabis components.
Conclusions:
- Nanotechnology presents a promising solution to overcome limitations in medical cannabis administration.
- Nanocarrier systems can significantly improve bioavailability, solubility, and targeted delivery of cannabinoids.
- This approach facilitates innovative interventions and precision medicine in cannabis-based therapies.
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