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Updated: Jun 11, 2025

A Hydrogen-Deuterium Exchange Mass Spectrometry HDX-MS Platform for Investigating Peptide Biosynthetic Enzymes
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Deuterated Drugs: Isotope Distribution and Impurity Profiles

William W Wood1

  • 1Wakefield Chemistry Consulting LLC, Bel Air, Maryland 21015, United States.

Journal of Medicinal Chemistry
|October 2, 2024
PubMed
Summary

Lower isotopologues are common in deuterated active pharmaceutical ingredients (APIs). A distribution profile, rather than overall enrichment, offers a more accurate description of these compounds, integrating lower isotopologues as part of the API.

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