Impact Factors of Blood Copeptin Levels in Health and Disease States

Copeptin, the C-terminal glycopeptide of provasopressin, is released into the circulation in an equimolar manner with arginine vasopressin (AVP) when fluid homeostasis changes or has somatic stress. Copeptin is considered a potential alternative to AVP due to its advantages in facilitating assays. Although there have been several studies and reviews that have focused on the marker potential of copeptin in diseases involving changes in AVP, studies on its characteristics and factors that may influence its secretion have not been reviewed before.

We summarize the influencing factors associated with copeptin levels in healthy and disease states, show the changes in copeptin levels under different physiologic and pathophysiologic conditions, calculate the changes in copeptin levels under different physiologic and pathophysiologic conditions, and compare them according to the type of stimuli. We also report research advances in copeptin changes in the diagnosis and prognosis of endocrine-related diseases.

Males have higher copeptin levels. Decreased copeptin levels are mainly caused by reduced blood volume and some diseases (eg, obesity). Under normal physiologic conditions, the effects of stress, endocrine axis stimulation, and blood volume increase on copeptin levels gradually increase. Under severe disease conditions (eg, sepsis), copeptin would remain at consistently high levels under compound stimuli and these elevated levels are associated with a poor prognosis of the disease.

Summarizing the influencing factors of copeptin can help us better understand the biologic features of copeptin and the similarities and differences between AVP and copeptin.