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Updated: Jun 11, 2025

Visualization of Flow Field Around a Vibrating Pipeline Within an Equilibrium Scour Hole
Published on: August 26, 2019
Braids and beyond: a comprehensive study on pipeline device braid stability from PREMIER data
Fernanda Rodriguez-Erazú1,2, Gustavo M Cortez1,3, Demetrius K Lopes4
1Lyerly Neurosurgery, Baptist Medical Center Downtown, Jacksonville, Florida, USA.
Background:
The pipeline embolization device (PED) has been increasingly used to treat brain aneurysms; however, concerns have been raised about braid stability with newer drawn filled tubing technology devices.
Objective:
To evaluate braid stability of PED early generations using data from the PREMIER trial.
Methods:
All consecutive intracranial aneurysms treated with PED (Classic and Flex) within the PREMIER trial were reviewed for braid stability (fish mouthing, foreshortening, braid bump, braid collapsing). Immediate postprocedure cone-beam CT and angiography were compared with 1- and 2- years' follow-up. Analyses included safety, measured with the modified Rankin Scale (mRS) score, including +1 mRS point and a good clinical outcome (mRS score 0-2), vessel stenosis ≥50%, effectiveness measured with Raymond-Roy Scale, and re-treatment rates.
Results:
133/141 aneurysms had a complete dataset. 8/133 (6%) aneurysms showed braid deformations. Inter-reader agreement was excellent (κ=0.83). Braid deformations were statistically significantly associated with in-stent vessel stenosis >50% (P=0.029), without impact on effectiveness or safety. Fish mouthing was found in 1/133 (0.75%) at 1 year, causing >50% vessel stenosis. Foreshortening occurred in 6/133 (4.5%), and braid bump in 1/133 (0.75%) associated with severe in-stent stenosis. Four other cases (3.0%) of asymptomatic in-stent stenosis due to neointimal hyperplasia were seen without braid changes. No new braid stability deformations were found at the 2-year follow-up.
Conclusion:
Our study demonstrates excellent braid stability among patients treated with the PED Classic and Flex in the PREMIER trial. Within the uncommon braid changes observed, none affected the PED safety or efficacy.
Trial Registration Number:
NCT02186561.
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