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Dual DNA Rulers to Study the Mechanism of Ribosome Translocation with Single-Nucleotide Resolution
Published on: July 8, 2019
Structural Perspective of the Double-Stranded RNA Transport Mechanism by SID-1 Family Proteins
Yoshinori Hirano1, Toshiyuki Shimizu1
1Graduate School of Pharmaceutical Sciences, The University of Tokyo.
Abstract:
The systemic RNA interference defective 1 (SID-1) family proteins are putative double-stranded RNA (dsRNA) transporters. Two mammalian homologs, SIDT1 and SIDT2 have been linked to many functions such as innate immune responses, microRNA uptake and lysosomal degradation of RNA/DNA whereas Caenorhabditis elegans SID-1 is essential for systemic RNA interference. However, dsRNA uptake mechanism is largely unknown. In this review, we discuss our current understanding of the molecular functions of SID-1 family proteins at a structure level, which highlights recent structural studies.
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