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Strategic electrochemical oxidation of vinblastin sulfate (an anticancer drug) via PVP-functionalized strontium oxide
Sana-Ul-Nisa Lanjar1, Amber R Solangi1, Nahjul Batool2
1National Centre of Excellence in Analytical Chemistry, University of Sindh Jamshoro 76080 Pakistan amber.solangi@usindh.edu.pk.
Abstract:
Cancer is a primary cause of death worldwide, and considerably impacts mortality rates in low- and middle-income countries. The rise in chemotherapeutic patients and toxicity of cytotoxic agents highlight the need for reliable analytical methods to detect these compounds. The current study presents a simple and straightforward method for producing polyvinylpyrrolidone functionalized strontium oxide nanoparticles (PVP-SrO NPs). The synthesized PVP-SrO NPs were applied as a sensitive sensor to detect vinblastin sulfate (VNB) (an anticancer drug). The synthesized PVP-SrO NPs were characterized using different characterization techniques. Fourier transform infrared spectroscopy (FTIR) confirms the functionality of synthesized PVP-SrO NPs. The sharp intense peaks of X-ray diffraction spectroscopy (XRD) confirm the crystalline nature of NPs, scanning electron microscopy (SEM) confirm the nanobeads like morphology, and energy dispersive spectroscopy (EDS) reveals the presence of Sr and O at 68.3% and 23% respectively. The electrochemical impedance spectroscopy and cyclic voltammetry studies revealed that the PVP-SrO/GCE is more conductive than bare GCE with an R ct value of 960.4 Ω compared to 2440 Ω. The sensor exhibited a wide linear dynamic range for VNB (0.05 to 60 μM) with low LOD 0.005 μM, and LOD 0.017 μM. The proposed sensor was successfully used for monitoring VNB in human blood serum samples with a satisfactory percent recovery from 96% to 103%. The fabricated sensor exhibits better performance than the reported sensors in terms of processing, simplicity, cost-effectiveness, energy consumption, and enhanced efficacy in a very short time.
Insights
Researchers developed polyvinylpyrrolidone functionalized strontium oxide nanoparticles (PVP-SrO NPs) as a novel sensor. This sensor accurately detects the anticancer drug vinblastine sulfate (VNB) in human blood serum.
Area of Science:
- Nanotechnology and Materials Science
- Analytical Chemistry
- Biomedical Engineering
Background:
- Cancer is a leading cause of death globally, increasing the demand for effective chemotherapeutic treatments.
- The toxicity of cytotoxic agents necessitates reliable analytical methods for drug monitoring in patients.
- Developing sensitive and cost-effective sensors is crucial for therapeutic drug monitoring.
Purpose of the Study:
- To synthesize and characterize polyvinylpyrrolidone functionalized strontium oxide nanoparticles (PVP-SrO NPs).
- To utilize PVP-SrO NPs as a sensor for the sensitive detection of vinblastine sulfate (VNB).
- To evaluate the sensor's performance in detecting VNB in human blood serum samples.
Main Methods:
- Synthesis of PVP-SrO NPs using a simple and straightforward method.
- Characterization of NPs using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction spectroscopy (XRD), scanning electron microscopy (SEM), and energy dispersive spectroscopy (EDS).
- Electrochemical analysis using electrochemical impedance spectroscopy and cyclic voltammetry to assess sensor conductivity and VNB detection capabilities.
Main Results:
- Successful synthesis and characterization of PVP-SrO NPs with confirmed functionality, crystalline nature, and nanobead morphology.
- The PVP-SrO/GCE sensor demonstrated enhanced conductivity compared to bare GCE.
- The sensor exhibited a wide linear dynamic range (0.05–60 μM) for VNB detection with a low limit of detection (LOD) of 0.005 μM.
- High percent recovery (96–103%) confirmed the sensor's accuracy in detecting VNB in human blood serum.
Conclusions:
- The fabricated PVP-SrO NPs sensor offers a sensitive, selective, and cost-effective method for detecting vinblastine sulfate.
- The sensor's performance, including processing simplicity and enhanced efficacy, surpasses previously reported sensors.
- This novel sensor holds significant potential for therapeutic drug monitoring in clinical settings.
