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Updated: Jul 12, 2026
Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles
Published on: June 2, 2023
Ginger-derived nanovesicles attenuate osteoarthritis progression by inhibiting oxidative stress via the Nrf2 pathway
Yiming Zeng1, Shun Yu2, Lin Lu3
1Shanghai Key Laboratory of Orthopedic Implants, Department of Orthopedics, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
Abstract:
Aim: Osteoarthritis (OA) is a common degenerative joint disease. Previous studies demonstrated ginger-derived exosome-like nanovesicles (GDN) showed therapeutic effects in degenerative diseases. However, it remains unknown whether GDN could alleviate OA progression.Materials & methods: In this study, GDN were obtained and characterized. Then we evaluated the effects of GDN in tert-butyl hydroperoxide (TBHP)-induced chondrocytes, posttraumatic OA rat model and ex vivo cultured human OA cartilage explants.Results: We demonstrated GDN promoted cartilage anabolism and alleviated oxidative stress in TBHP-induced chondrocytes and OA rat. Our results also showed GDN exhibited protective effects in cultured cartilage explants. Furthermore, we verified the Nrf2 pathway was associated with protective effects of GDN.Conclusion: Altogether, our findings demonstrated GDN hold great potential for OA treatment.
Insights
Ginger-derived nanovesicles (GDN) show promise for treating osteoarthritis (OA). These nanoparticles promote cartilage health and reduce oxidative stress, offering a potential new therapy for this degenerative joint disease.
Area of Science:
- Biomedical Engineering
- Regenerative Medicine
- Osteoarthritis Research
Background:
- Osteoarthritis (OA) is a prevalent degenerative joint disease.
- Ginger-derived nanovesicles (GDN) have demonstrated therapeutic potential in other degenerative conditions.
- The efficacy of GDN in mitigating OA progression requires investigation.
Purpose of the Study:
- To investigate the therapeutic potential of ginger-derived nanovesicles (GDN) in osteoarthritis (OA).
- To evaluate the effects of GDN on chondrocytes, an OA rat model, and human OA cartilage explants.
Main Methods:
- GDN were isolated and characterized.
- The effects of GDN were assessed in tert-butyl hydroperoxide (TBHP)-induced chondrocytes.
- GDN efficacy was evaluated in a post-traumatic OA rat model and ex vivo human OA cartilage explants.
Main Results:
- GDN promoted cartilage anabolism and alleviated oxidative stress in both cellular and animal models of OA.
- GDN demonstrated protective effects on ex vivo cultured human OA cartilage.
- The Nrf2 pathway was identified as a mechanism underlying the protective effects of GDN.
Conclusions:
- Ginger-derived nanovesicles (GDN) exhibit significant potential for the treatment of osteoarthritis.
- GDN promote cartilage health and combat oxidative stress, key factors in OA.
- Further research into GDN as an OA therapeutic is warranted.
