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Advances in non-invasive imaging for dermatofibrosarcoma protuberans: A review
Yanci A Algarin1, Anika Pulumati2, Jiali Tan3
1Eastern Virginia Medical School, Norfolk, Virginia, USA.
The Australasian Journal of Dermatology
|October 3, 2024
Summary
Ultrasound (US) and Magnetic Resonance Imaging (MRI) are key for assessing dermatofibrosarcoma protuberans (DFSP) and planning surgery. Advanced imaging like PET-CT shows promise for managing recurrent DFSP and treatment response.
Area of Science:
- Oncology
- Radiology
- Surgical Pathology
Background:
- Dermatofibrosarcoma protuberans (DFSP) is a rare, locally aggressive soft tissue sarcoma.
- DFSP exhibits infiltrative growth and a high recurrence rate, necessitating precise management.
- Accurate assessment of DFSP extent is crucial for effective surgical planning and treatment.
Purpose of the Study:
- To evaluate the efficacy of nine imaging modalities for dermatofibrosarcoma protuberans (DFSP) assessment.
- To compare the diagnostic capabilities of various imaging techniques in DFSP.
- To inform optimal imaging strategies for DFSP preoperative planning and recurrence monitoring.
Main Methods:
- Systematic review of nine imaging modalities: Ultrasound (US), High-Frequency Doppler Ultrasound (HFUS), Computed Tomography (CT), Positron Emission Tomography-Computed Tomography (PET-CT), Magnetic Resonance Imaging (MRI), High-Resolution MRI (HR-MRI), Magnetic Resonance Spectroscopy (MRS), Optical Coherence Tomography (OCT), and Dermatoscopy.
- Analysis of imaging performance in detecting tumor boundaries, muscle invasion, depth, and metastasis.
- Comparison of sensitivity and specificity for key modalities like US and MRI.
Main Results:
- Ultrasound (US) excels in initial evaluation, detecting muscle invasion (81.8% sensitivity) and defining tumor borders (100% specificity).
- Magnetic Resonance Imaging (MRI) is valuable for preoperative assessment and recurrence monitoring, accurately assessing tumor depth (67% sensitivity, 100% specificity).
- Computed Tomography (CT) is used for suspected bone involvement or metastasis; PET-CT aids in monitoring advanced/recurrent DFSP and treatment response.
Conclusions:
- Ultrasound (US), MRI, and CT are primary imaging modalities for dermatofibrosarcoma protuberans (DFSP) management.
- Emerging techniques (HR-MRI, PET-CT, MRS, OCT) show potential for refining diagnosis and surgical planning.
- Multimodal imaging integration may enhance DFSP management, especially for complex cases, requiring further research.
Keywords:
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