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Related Experiment Videos

Noncoding RNAs and diabetic kidney disease.

Jun Wada1

  • 1Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Kita-ku, Okayama, Japan.

Journal of Diabetes Investigation
|October 3, 2024
PubMed
Summary
This summary is machine-generated.

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Altered regulatory RNAs (miRNAs, lncRNAs, circRNAs) are linked to diabetes and its complications. These non-coding RNAs show potential as diagnostic markers and therapeutic targets for diabetic kidney disease (DKD).

Area of Science:

  • Biochemistry
  • Genetics
  • Molecular Biology

Background:

  • Diabetes mellitus and its complications, including diabetic kidney disease (DKD), represent a significant global health burden.
  • Altered expression of regulatory RNAs, such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), has been implicated in the pathogenesis of diabetes and its complications.

Purpose of the Study:

  • To review and discuss recently identified non-coding RNAs (ncRNAs) involved in the onset and progression of diabetic kidney disease (DKD).
  • To highlight the potential of these ncRNAs as diagnostic and prognostic biomarkers, as well as therapeutic targets for DKD.

Main Methods:

  • Comprehensive literature review of recent studies investigating ncRNAs in human and animal models of diabetes and DKD.
  • Analysis of data from various biological samples including serum, plasma, whole blood, and tissues.

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Main Results:

  • Numerous miRNAs, lncRNAs, and circRNAs show altered expression patterns in diabetes and DKD.
  • These ncRNAs are detected in diverse biological samples, indicating their potential as accessible biomarkers.

Conclusions:

  • Regulatory ncRNAs are key players in the development and progression of DKD.
  • Identified ncRNAs hold significant promise as novel diagnostic markers, prognostic indicators, and therapeutic targets for managing DKD.