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Author Spotlight: Exploring Press Needle Efficacy and Underlying Molecular Pathways
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Understanding how the immune system environment is controlled in high myopia cases.

Xin Qiao1, Wahid Shah2, Xiaoqin Gao1

  • 1Shanxi Eye Hospital Affiliated to Shanxi Medical University, Taiyuan 030002, China.

International Immunopharmacology
|October 3, 2024
PubMed
Summary

High myopia (HM) involves eye axis extension and poses a global health risk. This review highlights the immune system's crucial role in HM development and potential immune-modulating treatments.

Keywords:
High myopiaImmune cellsImmune factorInflammation

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Area of Science:

  • Ophthalmology and Immunology
  • Pathogenesis of High Myopia

Background:

  • High myopia (HM) is a significant eye condition characterized by axial elongation, leading to severe visual impairment and increased risk of ocular complications.
  • While genetic and environmental factors are known contributors, recent evidence points to the immune system's critical role in HM pathogenesis.

Purpose of the Study:

  • To review the intricate interplay between cytokines, immune cells, and the ocular microenvironment in the context of high myopia.
  • To explore immunomodulatory treatments for mitigating HM progression and its associated complications.

Main Methods:

  • Comprehensive review of current scientific literature focusing on the immune system's involvement in high myopia.
  • Analysis of studies investigating cytokine and immune cell interactions within the eye in HM patients.

Main Results:

  • The immune system and its microenvironment play a critical, multifactorial role in the development of high myopia.
  • Specific immune pathways and cellular interactions are implicated in the pathogenesis of HM and its complications.

Conclusions:

  • Understanding the immune system's function in HM is essential for developing novel therapeutic strategies.
  • Targeted immunomodulatory interventions hold promise for personalized treatments in high myopia management.