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Vaccination Coverage, Timeliness and Adverse Events Following Immunization in Children with Medical Conditions -

Yudan Song1, Xiang Zeng2, Shaonan Liu3

  • 1National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), Center for National Immunization Program, Chinese Center for Disease Control and Prevention & Chinese Academy of Preventive Medicine, Beijing, China.

China CDC Weekly
|July 11, 2026
PubMed

Insights

Children with medical conditions have high vaccination rates, but those with brain, immune, or congenital disorders are at higher risk. Improving vaccination practices for these vulnerable children is crucial for preventing diseases.

Area of Science:

  • Pediatrics
  • Immunology
  • Public Health

Background:

  • Children with underlying medical conditions are susceptible to vaccine-preventable diseases.
  • Undertaking vaccination is essential for this population to mitigate health risks.

Purpose of the Study:

  • To evaluate vaccination coverage and timeliness in a large cohort of children with medical conditions.
  • To identify specific subgroups of children with medical conditions who may have lower vaccination rates.
  • To analyze delays in vaccination and adverse events following immunization.

Main Methods:

  • A multicenter retrospective study was conducted.
  • Data from 24,966 children with various medical conditions were analyzed.
  • Vaccination coverage, timeliness, delays, and adverse events were assessed.

Main Results:

  • Median coverage for 10 National Immunization Program vaccines was 97.33%, with timely completion at 89.21%.
  • Children with brain, immune, or congenital disorders showed significantly lower vaccination coverage.
  • Vaccination delays were more pronounced after diagnosis compared to before diagnosis.
  • The rate of adverse events following immunization was 23.7 per 100,000 doses administered.

Conclusions:

  • While overall vaccination coverage is high, specific vulnerable groups require targeted interventions.
  • Addressing post-diagnosis vaccination delays is critical for improving immunization rates in children with complex medical conditions.
  • Further research and integration of advanced practices are needed to enhance vaccination uptake in these populations.
Abstract

Keywords:
ChildrenMedical ConditionsVaccination

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