One-pot transfer hydrogenation and reductive amination of polyenals
Juntao Yang1, Miaomiao Tian1, Junbiao Chang1
1State Key Laboratory of Antiviral Drugs, Pingyuan Laboratory, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, China. liubingxian@htu.edu.
Abstract:
The efficient preparation of long-chain amines via a one-step transfer-hydrogenation/reductive-amination reaction (THRA) of polyenals has been achieved. This strategy, which combines transfer hydrogenation and reductive amination, significantly enhances the synthetic efficiency of amino compounds. Additionally, this protocol offers a practical method for carbon-chain elongation/amination to construct long-chain amino compounds. The reaction system exhibits remarkable versatility in substrate scope using a non-noble ruthenium catalyst with formate and isopropanol as hydrogen sources, making it an appealing method for drug synthesis and molecular modification.
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