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Infantile Hypertrophic Pyloric Stenosis Without Metabolic Alkalosis: A Report of Two Cases
Ruhi Shaligram1, Sudhir Malwade1, Balakrushna P Garud1
1Pediatrics, Dr. D.Y. Patil Medical College, Hospital and Research Centre, Pune, IND.
Insights
Infantile hypertrophic pyloric stenosis (IHPS) can present with metabolic acidosis, not just alkalosis. This finding challenges typical biochemical expectations for IHPS, suggesting complex underlying mechanisms.
Area of Science:
- Pediatrics
- Gastroenterology
- Biochemistry
Background:
- Infantile hypertrophic pyloric stenosis (IHPS) classically causes gastric outlet obstruction.
- Typical IHPS biochemical findings include hypochloremic, hypokalemic metabolic alkalosis.
- This presentation can complicate diagnosis and management.
Abstract:
Infantile hypertrophic pyloric stenosis (IHPS) is a condition typically characterized by hypertrophy of the pylorus, leading to gastric outlet obstruction and forceful, nonbilious vomiting in young infants. This case series reports two infants with IHPS who exhibited metabolic acidosis, deviating from the classical biochemical presentation of hypochloremic, hypokalemic metabolic alkalosis. The unusual occurrence of metabolic acidosis in these cases suggests the possibility of alternative or additional pathophysiological mechanisms at play. Such deviations from the expected biochemical profile highlight the complexity of IHPS and the need for a broader diagnostic perspective.
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