Jove
Visualize
Contact Us

Related Concept Videos

Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Porphyrin-lipid nanotheranostics for multimodal imaging of nodal disease in preclinical oral cancers.

Theranostics·2026
Same author

Poly(sulfobetaine-<i>co</i>-oligoethylene Glycol Methyl Ether Methacrylate) Copolymers with Improved Anti-Fouling and Anti-Coagulant Properties.

Biomacromolecules·2026
Same author

Discovery and Characterization of Interleukin-4-Specific Affibodies for Affinity-Controlled Protein Release and Macrophage Polarization.

bioRxiv : the preprint server for biology·2026
Same author

Nanovesicle-Based Delivery of Magnesium Chlorophyllin for Photodynamic Inactivation in Agriculture.

Small science·2026
Same author

Uncertainty-Aware Learning of Multiple Conditions as a Framework for Streamlined Retention Time Prediction to Accelerate Method Development.

Analytical chemistry·2026
Same author

Ultrasound-triggered drug delivery: recent developments and opportunities.

Therapeutic delivery·2025
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 11, 2026

Generation of Cationic Nanoliposomes for the Efficient Delivery of In Vitro Transcribed Messenger RNA
08:29

Generation of Cationic Nanoliposomes for the Efficient Delivery of In Vitro Transcribed Messenger RNA

Published on: February 1, 2019

10.0K

Corked Microcapsules Enabling Controlled Ultrasound-Mediated Protein Delivery.

Andrew Singh1, Jonathan Dorogin1, Kayla Baker1

  • 1Department of Chemical Engineering, McMaster University, 1280 Main St. W., Hamilton, Ontario L8S 4L7, Canada.

ACS Applied Materials & Interfaces
|October 4, 2024
PubMed
Summary

Researchers developed novel microcapsules using electrospraying, featuring silica "corks" for controlled ultrasound-triggered drug release. This method enables tunable, pulsatile protein delivery, overcoming limitations of burst release profiles in drug delivery systems.

Keywords:
controlled releaseelectrohydrodynamicsmicrocapsulesprotein deliveryultrasound

More Related Videos

Assembly and Operation of an Acoustofluidic Device for Enhanced Delivery of Molecular Compounds to Cells
07:16

Assembly and Operation of an Acoustofluidic Device for Enhanced Delivery of Molecular Compounds to Cells

Published on: January 21, 2021

3.0K
Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release
06:02

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

Published on: June 12, 2021

3.8K

Related Experiment Videos

Last Updated: Jun 11, 2026

Generation of Cationic Nanoliposomes for the Efficient Delivery of In Vitro Transcribed Messenger RNA
08:29

Generation of Cationic Nanoliposomes for the Efficient Delivery of In Vitro Transcribed Messenger RNA

Published on: February 1, 2019

10.0K
Assembly and Operation of an Acoustofluidic Device for Enhanced Delivery of Molecular Compounds to Cells
07:16

Assembly and Operation of an Acoustofluidic Device for Enhanced Delivery of Molecular Compounds to Cells

Published on: January 21, 2021

3.0K
Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release
06:02

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

Published on: June 12, 2021

3.8K

Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Nanotechnology

Background:

  • Ultrasound offers a noninvasive method for triggering drug delivery.
  • Current ultrasound-triggered systems often exhibit uncontrolled burst release.
  • Need for precise control over drug release kinetics is critical.

Purpose of the Study:

  • To develop ultrasound-responsive microcapsules with controlled release capabilities.
  • To investigate the potential for pulsatile and on-demand drug delivery.
  • To address the limitations of burst release in existing systems.

Main Methods:

  • Fabrication of protein-loaded microcapsules using submerged electrospraying.
  • Incorporation of silica "corks" within the microcapsule shell.
  • Assessment of drug release profiles triggered by varying ultrasound pulse parameters in a phantom tissue mimic.

Main Results:

  • Silica corks enabled ultrasound-triggered release of bovine serum albumin.
  • Release rate increased 15- to 23-fold with ultrasound pulses compared to no ultrasound.
  • Drug release decreased upon removal of the ultrasound stimulus.
  • Demonstrated proportionality between ultrasound pulses and release extent.

Conclusions:

  • The developed corked microcapsules offer controlled, pulsatile drug release triggered by ultrasound.
  • This technology shows promise for on-demand drug delivery applications.
  • Low cytotoxicity of components supports potential clinical translation.