Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Phase Transitions: Vaporization and Condensation02:39

Phase Transitions: Vaporization and Condensation

17.5K
The physical form of a substance changes on changing its temperature. For example, raising the temperature of a liquid causes the liquid to vaporize (convert into vapor). The process is called vaporization—a surface phenomenon. Vaporization occurs when the thermal motion of the molecules overcome the intermolecular forces, and the molecules (at the surface) escape into the gaseous state. When a liquid vaporizes in a closed container, gas molecules cannot escape. As these gas phase...
17.5K
¹H NMR of Conformationally Flexible Molecules: Temporal Resolution00:52

¹H NMR of Conformationally Flexible Molecules: Temporal Resolution

811
At room temperature, the chair conformer of cyclohexane undergoes rapid ring flipping between two equivalent chair conformers at a rate of approximately 105 times per second. These two chair conformers are in equilibrium. The rapid ring flipping results in the interconversion of the axial proton to an equatorial proton and an equatorial to the axial proton. Such interconversions are too rapid and cannot be detected on the NMR timescale. Hence, the NMR spectrometer cannot distinguish between the...
811
Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

2.5K
2.5K
Phase Transitions: Sublimation and Deposition02:33

Phase Transitions: Sublimation and Deposition

17.0K
Some solids can transition directly into the gaseous state, bypassing the liquid state, via a process known as sublimation. At room temperature and standard pressure, a piece of dry ice (solid CO2) sublimes, appearing to gradually disappear without ever forming any liquid. Snow and ice sublimate at temperatures below the melting point of water, a slow process that may be accelerated by winds and the reduced atmospheric pressures at high altitudes. When solid iodine is warmed, the solid sublimes...
17.0K
¹H NMR of Conformationally Flexible Molecules: Variable-Temperature NMR01:15

¹H NMR of Conformationally Flexible Molecules: Variable-Temperature NMR

1.1K
The axial and equatorial protons in cyclohexane can be distinguished by performing a variable-temperature NMR experiment. In this process, except for one proton, the remaining eleven protons are replaced by deuterium. The deuterium substitution avoids the possible peak splitting caused by the spin-spin coupling between the adjacent protons. The remaining proton flips between the axial and equatorial positions.
1.1K
Protein Folding01:25

Protein Folding

7.8K
Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation, critical to its biological function. Interactions between its constituent amino acids guide protein folding, and hence the protein structure is primarily dependent on its amino acid sequence.
Protein Structure Is Critical to Its Biological Function
Proteins perform a wide range of biological functions such as catalyzing chemical reactions, providing...
7.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Critical Role of the 2'-OH group in Phase Separation and Percolation Transitions of RNA.

bioRxiv : the preprint server for biology·2026
Same author

Strengthening the philosophical basis of graduate science education.

Trends in biochemical sciences·2026
Same author

Development of RNA-targeting small-molecule therapeutics.

Trends in pharmacological sciences·2026
Same author

Systemic Delivery of Functional Proteins Into Plants Using an Engineered Membrane Translocation Domain.

Plant biotechnology journal·2026
Same author

Decoupling phase separation and fibrillization preserves activity of biomolecular condensates.

Nature communications·2026
Same author

Histone H3 tail charge patterns govern nucleosome condensate formation and dynamics.

Nucleic acids research·2026

Related Experiment Video

Updated: Jun 11, 2025

Author Spotlight: Evaluation of Protein-Condensate Dynamics in Live Human Cells
06:48

Author Spotlight: Evaluation of Protein-Condensate Dynamics in Live Human Cells

Published on: January 5, 2024

3.4K

RNA-driven phase transitions in biomolecular condensates.

Gable M Wadsworth1, Sukanya Srinivasan1, Lien B Lai2

  • 1Department of Physics, The State University of New York at Buffalo, Buffalo, NY, USA.

Molecular Cell
|October 4, 2024
PubMed
Summary
This summary is machine-generated.

RNA and protein condensates are crucial for cell function but often studied from a protein perspective. This review emphasizes RNA-driven phase transitions, highlighting their role in cellular regulation and therapeutic potential.

Keywords:
RNA chaperonesRNP granulesgene regulationhelicasesliquid-liquid phase separationpercolationstress granules

More Related Videos

Chemical Dimerization-Induced Protein Condensates on Telomeres
08:52

Chemical Dimerization-Induced Protein Condensates on Telomeres

Published on: April 12, 2021

3.1K
Author Spotlight: Developing Synthetic Cells from Programmable Amphiphilic DNA Nanostructures
08:02

Author Spotlight: Developing Synthetic Cells from Programmable Amphiphilic DNA Nanostructures

Published on: May 31, 2024

705

Related Experiment Videos

Last Updated: Jun 11, 2025

Author Spotlight: Evaluation of Protein-Condensate Dynamics in Live Human Cells
06:48

Author Spotlight: Evaluation of Protein-Condensate Dynamics in Live Human Cells

Published on: January 5, 2024

3.4K
Chemical Dimerization-Induced Protein Condensates on Telomeres
08:52

Chemical Dimerization-Induced Protein Condensates on Telomeres

Published on: April 12, 2021

3.1K
Author Spotlight: Developing Synthetic Cells from Programmable Amphiphilic DNA Nanostructures
08:02

Author Spotlight: Developing Synthetic Cells from Programmable Amphiphilic DNA Nanostructures

Published on: May 31, 2024

705

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • Cellular condensates, formed by RNAs and RNA-binding proteins, are liquid-like droplets involved in vital physiological processes.
  • Dysregulation of these ribonucleoprotein (RNP) condensates is linked to various diseases.
  • Current research predominantly focuses on protein-centric mechanisms, overlooking RNA's role.

Purpose of the Study:

  • To highlight recent advancements in RNP condensate biology.
  • To emphasize the critical role of RNA-driven phase transitions in condensate formation and function.
  • To explore future directions and therapeutic applications of RNA condensates.

Main Methods:

  • Literature review of recent developments in RNP condensate biology.
  • Focus on studies investigating RNA's influence on phase transitions.
  • Analysis of emerging research on RNA condensate roles and bioengineering.

Main Results:

  • RNA molecules are central to the formation, regulation, and function of RNP condensates.
  • RNA-driven phase transitions are key determinants of condensate properties.
  • Emerging evidence points to RNA condensates in spatiotemporal cellular regulation.

Conclusions:

  • Understanding RNA's role in phase transitions is crucial for comprehending RNP condensate biology.
  • RNA-driven condensates offer potential for developing novel RNA-based therapeutics.
  • Further research into RNA condensates can unlock new strategies for disease treatment.