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Experimental models as a tool for research on sarcopenia: A narrative review
Janire Alonso-Puyo1, Oihane Izagirre-Fernandez1, Olatz Crende2
1Physiology Department, Faculty of Medicine and Nursery, University of the Basque Country (UPV/EHU), Barrio Sarriena, sn., Leioa 48940, Spain.
Ageing Research Reviews
|October 6, 2024
Summary
Experimental models are crucial for understanding sarcopenia, a muscle-wasting disease affecting aging populations. Research into these models aids in early diagnosis and potential treatments for sarcopenia.
Area of Science:
- Gerontology
- Musculoskeletal Disorders
- Molecular Biology
Background:
- Sarcopenia, a decline in muscle mass and function, impacts quality of life and public health due to global population aging.
- Early diagnosis of sarcopenia is vital as it is a reversible condition.
- Current diagnostic methods like liquid and skeletal muscle biopsies have limitations in revealing tissue-specific molecular pathways.
Purpose of the Study:
- To review experimental models for sarcopenia research.
- To evaluate the advantages and disadvantages of various models.
- To highlight their potential in advancing sarcopenia diagnosis and treatment.
Main Methods:
- Narrative review of existing literature.
- Exploration of animal, cellular, and bioengineered tissue models.
- Consideration of genetic strategies like knock-in and knock-out.
Main Results:
- Experimental models offer valuable insights into molecular aspects of sarcopenia.
- Different models present unique advantages and limitations for studying muscle aging.
- These models can complement existing diagnostic tools.
Conclusions:
- Experimental models are essential for advancing sarcopenia research.
- They hold promise for improving early diagnosis, monitoring, and therapeutic strategies for sarcopenia.
- Further development and application of these models are encouraged.
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