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Updated: Jun 11, 2025

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
Published on: March 2, 2014
Flaviviruses manipulate mitochondrial processes to evade the innate immune response
RuthMabel Boytz1, Kadiatou Keita1, Joanna B Pawlak2
1Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT USA.
Abstract:
Mitochondria are essential eukaryotic organelles that regulate a range of cellular processes, from metabolism to calcium homeostasis and programmed cell death. They serve as essential platforms for antiviral signaling proteins during the innate immune response to viral infections. Mitochondria are dynamic structures, undergoing frequent fusion and fission processes that regulate various aspects of mitochondrial biology, including innate immunity. Pathogens have evolved sophisticated mechanisms to manipulate mitochondrial morphology and function to facilitate their replication. In this review, we examine the emerging literature on how flaviviruses modulate mitochondrial processes.
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