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Published on: December 29, 2015
Balancing acts: The posttranslational modification tightrope of flavivirus replication
RuthMabel Boytz1, Maudry Laurent-Rolle1,2
1Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, United States of America.
Abstract:
Posttranslational modifications (PTMs) such as phosphorylation, ubiquitination, SUMOylation, and ISGylation are involved in various cellular pathways, including innate immunity and disease processes. Many viruses have developed sophisticated mechanisms to modulate these host PTMs, either by inhibiting the interferon pathway or by enhancing the stability and function of viral proteins essential for replication. In this Pearl, we review the literature on how flaviviruses are impacted by and exploit posttranslational modifications to their advantage.
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