Related Experiment Video
Updated: Jun 11, 2025

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery
Published on: April 14, 2016
Effect of Preemptive Analgesia on Pain Perception in Children: A Randomized Controlled Trial
Mira Virda1, Anup Panda1, Kanu Kataria2
1Department of Pediatric and Preventive Dentistry, College of Dental Sciences and Research Centre, Ahmedabad, Gujarat, India.
Preemptive analgesia with Ibugesic Plus significantly reduced pain during and after primary tooth extraction in children. This approach offers a rational strategy for pediatric dental pain management, improving patient experience.
Area of Science:
- Pediatric Dentistry
- Pain Management
- Anesthesiology
Background:
- Minimizing pain and needle fear in children undergoing dental procedures is crucial.
- Positive experiences are essential for pediatric dental patients.
- This study evaluates premedication with Ibugesic Plus for local anesthesia and extraction in children.
Purpose of the Study:
- To assess the efficacy of preemptive analgesia in managing pain during local anesthesia administration and extraction.
- To evaluate the impact of Ibugesic Plus on pain perception in pediatric patients.
- To compare pain levels between children receiving preemptive analgesia and a placebo.
Main Methods:
- A randomized controlled trial involving 104 children aged 7-10 years requiring primary molar extraction.
- Group I received Ibugesic Plus syrup 30 minutes before extraction; Group II received a placebo (B-Folcin syrup).
- Pain levels, pulse rate, and SpO2 were measured using the Wong-Baker Faces Pain Rating Scale and pulse oximeter post-injection, post-extraction, and postoperatively.
Main Results:
- Pain scores were highest immediately after injection and extraction.
- Children receiving preemptive analgesics (Group I) reported significantly lower pain scores compared to the placebo group (Group II).
- Pain reduction was observed immediately after injection, after extraction, and 2 hours postoperatively.
Conclusions:
- Preemptive analgesic administration, such as with Ibugesic Plus, is an effective pain management strategy for primary tooth extractions.
- This approach can be considered a routine and rational method for managing pain in pediatric dental procedures.
- Preemptive analgesia can reduce postoperative pain in children undergoing dental treatments.
Related Concept Videos
Analgesia and Pain Management
Opioid Analgesics: Synthetic and Semisynthetic Opioids
Parenteral Anesthetics: Overview
Local Anesthetics: Clinical Application as Epidural Anesthesia
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...

