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An Intravital Microscopy-Based Approach to Assess Intestinal Permeability and Epithelial Cell Shedding Performance
Published on: December 3, 2020
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Increased Intestinal Inflammation and Permeability in Glaucoma
Zuo Wang1,2, Siqi Guo3, Chong He2,4
1Department of Clinical Laboratory, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, People's Republic of China.
Journal of Inflammation Research
|October 7, 2024
Summary
Glaucoma patients show increased gut inflammation and permeability, indicated by higher fecal lactoferrin and alpha-1 antitrypsin levels. These markers correlate with disease severity, suggesting a gut-retina axis link in glaucoma pathogenesis.
Area of Science:
- Ophthalmology
- Gastroenterology
- Microbiome Research
Background:
- Gut dysbiosis is linked to glaucoma development, often involving chronic intestinal inflammation and increased permeability.
- The specific relationship between intestinal inflammation/permeability markers and glaucoma requires further investigation.
Purpose of the Study:
- To investigate the association between fecal inflammation and permeability markers and glaucoma.
- To explore the correlation of these markers with glaucoma severity.
Main Methods:
- Quantified fecal lactoferrin (Lf) and alpha-1 antitrypsin (AAT) using ELISA in 114 glaucoma patients and 75 controls.
- Utilized logistic regression to assess biomarker association with glaucoma and severity (based on mean deviation).
Main Results:
- Glaucoma patients exhibited significantly elevated fecal Lf and AAT levels compared to controls.
- Fecal Lf and AAT positively correlated with glaucoma, with adjusted odds ratios indicating increased risk.
- Fecal Lf levels differed between moderate and severe glaucoma, while fecal AAT correlated with greater glaucomatous injury and larger vertical cup-to-disc ratio.
Conclusions:
- Findings suggest increased intestinal inflammation and permeability in glaucoma patients.
- This supports the role of the gut-retina axis in glaucoma pathogenesis.
- These biomarkers may offer new therapeutic targets for glaucoma.
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