Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

527
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
527
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

403
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
403
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

448
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
448
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

148
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
148
Factors Influencing Drug Absorption: Disease States and Pharmacology01:25

Factors Influencing Drug Absorption: Disease States and Pharmacology

453
Multiple disease states can significantly influence the oral drug absorption process by affecting blood flow and the functionality of the gastrointestinal (GI) system. Various GI diseases, including conditions that alter GI motility, such as diarrhea, decreased acid secretions (achlorhydria), and infections, have been associated with reduced drug absorption.
Substances such as alcohol and specific drugs, including antineoplastics, can also negatively impact drug absorption. For instance,...
453
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

194
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
194

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neutrophil-Mediated Inflammatory Response to Zinc Bone Implants: A Single-Cell Transcriptomic Landscape.

Advanced healthcare materials·2026
Same author

Impact of field number and monitor units per segment on magnetic resonance-guided hypofractionated stereotactic radiotherapy for brain metastases: plan quality, deliverability, and robustness trade-offs.

Quantitative imaging in medicine and surgery·2026
Same author

A molybdenum-promoted nickel-aluminum alloy catalyst for high-efficient hydrogenation reduction of nitrate to ammonia and nitrogen.

RSC advances·2026
Same author

Triazine and other herbicides in sediments of lower Laurentian Great Lakes - pre- and post-depositional mobility and in-situ degradation.

Environmental pollution (Barking, Essex : 1987)·2026
Same author

Biomass-Derived Hydrogels for Load-Bearing Connective Tissue Repair: Integrative Reinforcement, Bio-Functional Design, and Emerging Pathways Toward Clinical Translation.

Advanced healthcare materials·2026
Same author

The Proliferation and Adipogenic/Fibrogenic Fate Commitment of FAPs via an Autocrine LAMA2/ITGβ1-FAK Pathway.

Journal of agricultural and food chemistry·2026

Related Experiment Video

Updated: Jun 11, 2025

An Intravital Microscopy-Based Approach to Assess Intestinal Permeability and Epithelial Cell Shedding Performance
07:32

An Intravital Microscopy-Based Approach to Assess Intestinal Permeability and Epithelial Cell Shedding Performance

Published on: December 3, 2020

5.8K

Increased Intestinal Inflammation and Permeability in Glaucoma.

Zuo Wang1,2, Siqi Guo3, Chong He2,4

  • 1Department of Clinical Laboratory, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, People's Republic of China.

Journal of Inflammation Research
|October 7, 2024
PubMed
Summary

Glaucoma patients show increased gut inflammation and permeability, indicated by higher fecal lactoferrin and alpha-1 antitrypsin levels. These markers correlate with disease severity, suggesting a gut-retina axis link in glaucoma pathogenesis.

Keywords:
fecal alpha-1 antitrypsinfecal lactoferringlaucomaintestinal barrierintestinal inflammationintestinal permeability

More Related Videos

A Magnetic Microbead Occlusion Model to Induce Ocular Hypertension-Dependent Glaucoma in Mice
09:26

A Magnetic Microbead Occlusion Model to Induce Ocular Hypertension-Dependent Glaucoma in Mice

Published on: March 23, 2016

19.4K
Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

13.0K

Related Experiment Videos

Last Updated: Jun 11, 2025

An Intravital Microscopy-Based Approach to Assess Intestinal Permeability and Epithelial Cell Shedding Performance
07:32

An Intravital Microscopy-Based Approach to Assess Intestinal Permeability and Epithelial Cell Shedding Performance

Published on: December 3, 2020

5.8K
A Magnetic Microbead Occlusion Model to Induce Ocular Hypertension-Dependent Glaucoma in Mice
09:26

A Magnetic Microbead Occlusion Model to Induce Ocular Hypertension-Dependent Glaucoma in Mice

Published on: March 23, 2016

19.4K
Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

13.0K

Area of Science:

  • Ophthalmology
  • Gastroenterology
  • Microbiome Research

Background:

  • Gut dysbiosis is linked to glaucoma development, often involving chronic intestinal inflammation and increased permeability.
  • The specific relationship between intestinal inflammation/permeability markers and glaucoma requires further investigation.

Purpose of the Study:

  • To investigate the association between fecal inflammation and permeability markers and glaucoma.
  • To explore the correlation of these markers with glaucoma severity.

Main Methods:

  • Quantified fecal lactoferrin (Lf) and alpha-1 antitrypsin (AAT) using ELISA in 114 glaucoma patients and 75 controls.
  • Utilized logistic regression to assess biomarker association with glaucoma and severity (based on mean deviation).

Main Results:

  • Glaucoma patients exhibited significantly elevated fecal Lf and AAT levels compared to controls.
  • Fecal Lf and AAT positively correlated with glaucoma, with adjusted odds ratios indicating increased risk.
  • Fecal Lf levels differed between moderate and severe glaucoma, while fecal AAT correlated with greater glaucomatous injury and larger vertical cup-to-disc ratio.

Conclusions:

  • Findings suggest increased intestinal inflammation and permeability in glaucoma patients.
  • This supports the role of the gut-retina axis in glaucoma pathogenesis.
  • These biomarkers may offer new therapeutic targets for glaucoma.