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Acute severe hepatitis and COVID-19: case report
Saber Hmimass1, Maryeme Kadiri1, Mohamed Borahma1
1Department of Hepato-Gastroenterology C, Ibn Sina Hospital, Mohamed V University, Rabat, Morocco.
The Pan African Medical Journal
|October 7, 2024
Summary
Severe acute hepatitis and liver failure can occur in patients with COVID-19, even without prior liver issues. This study highlights potential multifactorial causes of liver injury in coronavirus disease 2019 patients.
Area of Science:
- Hepatology
- Infectious Diseases
- Critical Care Medicine
Background:
- Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, is a global health emergency.
- Liver test abnormalities are common in COVID-19 patients, irrespective of pre-existing liver conditions.
Observation:
- A 25-year-old male presented with abdominal pain and subsequently developed acute severe liver failure.
- Respiratory symptoms were not the initial presentation in this case.
Findings:
- COVID-19-associated liver injury is likely multifactorial.
- Potential mechanisms include systemic inflammation, hepatic hypoxia, and drug toxicity.
- Direct SARS-CoV-2 infection of hepatocytes is unlikely.
Implications:
- COVID-19 can manifest with severe liver injury, including acute hepatitis and liver failure.
- Clinicians should consider COVID-19 in the differential diagnosis of acute liver failure, even with atypical presentations.
- Early recognition and management of liver injury in COVID-19 are crucial.
