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Related Concept Videos

Anatomy of the Heart01:27

Anatomy of the Heart

The human heart is made up of three layers of tissue that are surrounded by the pericardium, a membrane that protects and confines the heart. The outermost layer, closest to the pericardium, is the epicardium. The pericardial cavity separates the pericardium from the epicardium. Beneath the epicardium is the myocardium, the middle layer, and the endocardium, the innermost layer. There are four chambers of the heart: the right atrium, the right ventricle, the left atrium, and the left ventricle.
Fascicle Arrangement in Skeletal Muscles01:25

Fascicle Arrangement in Skeletal Muscles

Fascicles are bundles of muscle fibers in a skeletal muscle. Muscle fascicle arrangement is directly associated with the power and range of motion of various muscles. The configuration of these fascicles can vary, leading to different functional outcomes.
The four primary types of muscle based on fascicle arrangement are:
Development of the Heart01:27

Development of the Heart

The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart tube by...
Anatomy of the Heart01:20

Anatomy of the Heart

The heart is a hollow, muscular organ approximately the size of a fist, consisting of four chambers. It is enclosed in the pericardium, a fibrous sac with two layers: the visceral and parietal pericardium, separated by a fluid-filled space containing serous fluid to reduce friction.
The heart has three layers: the innermost endocardium, the muscular myocardium, and the outer epicardium, all working together for optimal cardiac function.
Chambers of the Heart
The heart is made up of four...

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Capillary Force Lithography for Cardiac Tissue Engineering
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Multidirectional Filamented Light Biofabrication Creates Aligned and Contractile Cardiac Tissues.

Lewis S Jones1, Miriam Filippi1, Mike Yan Michelis1

  • 1Soft Robotics Laboratory, ETH Zurich, Tannenstrasse 3, Zurich, 8092, Switzerland.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|October 7, 2024
PubMed
Summary
This summary is machine-generated.

Researchers biofabricated 3D cardiac tissues using multidirectional light. This method creates aligned tissues with controlled contractility, advancing regenerative medicine and biohybrid robotics.

Keywords:
cardiac tissue engineeringcardiomyocytescell alignmentcontractile tissuesvolumetric bioprinting

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Area of Science:

  • Tissue Engineering
  • Biomedical Engineering
  • Regenerative Medicine

Background:

  • Biofabricating 3D cardiac tissues that mimic native myocardial tissue is a significant challenge.
  • Achieving controlled cellular alignment and contractility is crucial for functional cardiac tissue.
  • Existing methods face limitations in fabricating complex, aligned tissue structures.

Purpose of the Study:

  • To develop a novel biofabrication technique for creating 3D cardiac tissues with controlled, multidirectional cellular alignment.
  • To achieve directed or twisting contractility in biofabricated cardiac tissues.
  • To overcome limitations of light attenuation in fabricating larger, complex cardiac tissue constructs.

Main Methods:

  • Utilizing multidirectional filamented light projection for biofabrication.
  • Fabricating high-density cell constructs (up to 60 × 10^6 cells/mL).
  • Employing multidirectional light projection to overcome cell-induced light attenuation.

Main Results:

  • Successfully fabricated high-density 3D cardiac tissues with directed uniaxial contractility (3.8x).
  • Observed improved cell-to-cell connectivity, evidenced by 1.6x increased gap junction expression.
  • Fabricated larger, multi-layered tissues with multidirectional cellular alignment and torsional contractility.

Conclusions:

  • Multidirectional light projection offers a new strategy for rapid biofabrication of aligned cardiac tissues.
  • The developed approach enables controlled cellular alignment and contractility in engineered cardiac tissues.
  • This technique holds significant potential for applications in regenerative medicine and biohybrid robotics.