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Updated: Jun 11, 2025

Proton Transfer and Protein Conformation Dynamics in Photosensitive Proteins by Time-resolved Step-scan Fourier-transform Infrared Spectroscopy
Published on: June 27, 2014
Characterizing excited-state intramolecular proton transfer in 3-hydroxyflavone with ultrafast transient infrared
Valerie S Winkler1, Joseph A Fournier1
1Washington University in St. Louis, One Brookings Dr, St. Louis, MO 63130, USA. jfournier@wustl.edu.
Abstract:
Vibrational dynamics associated with excited-state intramolecular proton transfer in 3-hydroxyflavone and 3-hydroxy-2-(thiophen-2-yl)chromen-4-one are characterized with ultrafast transient infrared spectroscopy. The spectroscopic data reveal rapid (<100 fs) proton transfer dynamics in both species, followed by vibrational relaxation of the tautomer products within a few picoseconds. Coherent coupling of the shared proton to low-frequency modes along the hydrogen bond coordinate are also observed in the ground electronic states.
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