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BioPred: an R package for biomarkers analysis in precision medicine
Zihuan Liu1, Yan Sun1, Xin Huang1
1Data and Statistical Sciences, AbbVie Inc., North Chicago, IL, 60064, United States.
Summary:
The R package BioPred offers a suite of tools for subgroup and biomarker analysis in precision medicine. Leveraging Extreme Gradient Boosting (XGBoost) along with propensity score weighting and A-learning methods, BioPred facilitates the optimization of individualized treatment rules to streamline subgroup identification. BioPred also enables the identification of predictive biomarkers and obtaining their importance rankings. Moreover, the package provides graphical plots tailored for biomarker analysis. This tool enables clinical researchers seeking to enhance their understanding of biomarkers and patient population in drug development.
Availability And Implementation:
The package is available at CRAN and https://github.com/deeplearner0731/BioPred.
