Related Experiment Video
Updated: Jun 11, 2025
Assessment of Viability of Human Fat Injection into Nude Mice with Micro-Computed Tomography
Published on: January 7, 2015
Oral/Perioral Reactions to Injectable Soft Tissue Fillers: A Clinicopathological Multicentric Study
Fábio Ramoa Pires1, Aurélio Marcos Tsutyia Said2, Juliana de Noronha Santos Netto3
1Oral Pathology, School of Dentistry, Rio de Janeiro State University, and Post Graduation Program in Dentistry, Estácio de Sá University, Rio de Janeiro, Brazil.
Objective:
To analyze the characteristics of a series of oral reactions to injectable soft tissue fillers.
Materials And Methods:
Cases diagnosed as oral reactions to injectable soft tissue fillers were selected from eight Pathology laboratories. Information was retrieved from the laboratory charts and from the review of the hematoxylin and eosin-stained histological slides.
Results:
The 151 patients showed a mean age of 54.9 years, and 136 (90.1%) were females. Mean time of onset was 20.4 months, and the lips were the most frequent location (72.8%). Most cases presented as asymptomatic isolated nodules, with a mean size of 17.4 mm. Silicone (38.5%), polymethylmetacrylate (33%), and hyaluronic acid (11.9%) were the three most common fillers. Granulomas, foamy macrophages, and multinucleated giant cells were observed in 44%, 51.5%, and 65.3% of the cases, respectively. Time of onset was shorter for males (p = 0.033), and symptoms were common in the upper lip, buccal mucosa, and lower vestibule (p = 0.010). Foamy macrophages were more common in association with silicone and collagen (p < 0.001), whereas multinucleated giant cells were more common in association with polymethylmetacrylate, hydroxiapatite, and polylactic acid (p = 0.012).
Conclusion:
Clinicians should consider reactions to injectable soft tissue fillers when evaluating asymptomatic submucosal nodules affecting the lips of adult/older females.
