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Utility of Lymph Node Ratio in Predicting Biochemical Incomplete Clinical Response in Patients with Papillary Ca
Gopi Satya Sai Reddy Gontu1, Rajjyoti Das1, Tashnin Rahman1
1Department of Head & Neck Surgery, Dr Bhubneshwar Borooah Cancer Institute Guwahati, Guwahati, Assam India.
Summary
Lymph-node ratios in papillary thyroid cancer patients can predict incomplete biochemical response after surgery. This finding aids in planning aggressive follow-up and treatment strategies for better patient outcomes.
Area of Science:
- Oncology
- Endocrinology
- Surgical Pathology
Background:
- Papillary thyroid carcinoma with neck node involvement necessitates vigilant follow-up.
- Identifying predictors for biochemically incomplete response is crucial for optimizing patient management.
Purpose of the Study:
- To evaluate the predictive value of central and lateral lymph-node ratios.
- To assess their utility in determining clinical response after total thyroidectomy and neck dissection.
Main Methods:
- Retrospective cohort analysis of 51 papillary thyroid carcinoma patients with neck nodes.
- Patients underwent surgery and radioactive iodine (RAI) therapy.
- Median follow-up duration was 3 years.
Main Results:
- A statistically significant correlation was found between lymph-node ratios and clinical response.
- Lymph-node ratios demonstrated approximately 90% sensitivity and specificity.
- These ratios effectively predicted biochemically incomplete response.
Conclusions:
- Central and lateral compartment lymph-node ratios serve as reliable predictors.
- These ratios can forecast the occurrence of biochemically incomplete response in treated patients.
