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Updated: Jun 11, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Well-defined cobalt(II)-catalyzed synthesis of perimidine derivatives via acceptorless dehydrogenative annulation
Debjyoti Pal1, Rajashri Sarmah1, Avijit Mondal1
1Department of Chemistry, Indian Institute of Technology-Guwahati, Kamrup, Assam 781039, India. dsrimani@iitg.ac.in.
Abstract:
The versatility of the perimidine moiety offers a rich playground for researchers in fields ranging from medical science to industrial chemistry. Herein, we describe the first Co-catalyzed synthesis of 2,3-dihydro-1H-perimidine via acceptorless dehydrogenative annulation (ADA). Apart from featuring benzyl alcohol having different functionalities, heteroaryl and aliphatic alcohols also provide good yields. Our catalytic protocol is also suitable for different fatty alcohols for furnishing perimidine derivatives, keeping distal unsaturation intact. Several kinetic and control tests were carried out in order to understand the reaction sequence.
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