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Related Experiment Videos

Butorphanol/acetaminophen double-blind study in postoperative pain.

R E Young, J J Quigley, W A Archambault

    Journal of Medicine
    |January 1, 1979
    PubMed
    Summary

    This study found that an oral combination of butorphanol and acetaminophen provides superior pain relief compared to individual components or placebo in postoperative patients. This potent analgesic combination demonstrated minimal side effects.

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    Area of Science:

    • Pharmacology
    • Pain Management
    • Clinical Trials

    Background:

    • Postoperative pain management often requires effective analgesics.
    • Combination analgesics may offer improved efficacy and safety profiles.

    Purpose of the Study:

    • To evaluate the analgesic efficacy and safety of an oral butorphanol/acetaminophen combination.
    • To compare the combination product against individual components and placebo.

    Main Methods:

    • A double-blind, placebo-controlled study involving 120 postoperative patients.
    • Patients received either butorphanol/acetaminophen, butorphanol alone, acetaminophen alone, or placebo.
    • Pain relief was assessed over a 4-hour period.

    Main Results:

    • The butorphanol/acetaminophen combination was significantly more effective than butorphanol, acetaminophen, or placebo (p < 0.05).
    • Most treatments showed superiority to placebo over 4 hours, with acetaminophen showing significance at 2 hours.
    • A second study with a lower dose combination also proved significantly superior to placebo (p < 0.05).

    Conclusions:

    • The butorphanol/acetaminophen combination exhibits potent analgesic activity.
    • The combination demonstrates at least additive effects, with a suggestion of synergism.
    • This combination product offers an effective option for postoperative pain with a favorable side effect profile.

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