Related Experiment Video

Updated: Jun 11, 2025

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome
06:39

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome

Published on: October 3, 2018

9.8K

Pediatric Myelodysplastic Syndrome: Updated Classifications and Current Diagnosis and Treatment Challenges

Zaina Inam, Miao Pan, Yaser Diab

    Archives of Pathology & Laboratory Medicine
    |October 8, 2024
    PubMed

    Insights

    Pediatric myelodysplastic syndromes (MDSs) are distinct from adult forms, requiring evaluation for germline predisposition. Limited resources necessitate collaborative studies for better diagnosis and management of childhood MDS.

    Area of Science:

    • Pediatric Hematology
    • Oncology
    • Genetics

    Background:

    • Myelodysplastic syndromes (MDSs) are rare in children.
    • Pediatric MDS presents unique clinical manifestations and implications compared to adult MDS.

    Purpose of the Study:

    • To review the clinical features of pediatric MDS.
    • To explore the pathogenesis of pediatric MDS.
    • To outline the classification of pediatric MDS.

    Main Methods:

    • Review of published literature.
    • Incorporation of personal clinical experience.

    Main Results:

    • Pediatric MDS significantly differs from adult MDS.
    • Identifying underlying germline predisposition syndromes is crucial for classification and management.
    • Recognition, diagnosis, and management resources for pediatric MDS are limited.

    Conclusions:

    • Pediatric MDS requires a distinct approach from adult MDS.
    • Germline predisposition evaluation is critical for accurate classification and effective management.
    • Multi-institutional collaborative studies are essential to advance the understanding and care of pediatric MDS due to its rarity.
    Abstract

    More Related Videos

    Database-guided Flow-cytometry for Evaluation of Bone Marrow Myeloid Cell Maturation12:05

    Database-guided Flow-cytometry for Evaluation of Bone Marrow Myeloid Cell Maturation

    Published on: November 3, 2018

    11.5K
    Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies06:33

    Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies

    Published on: November 10, 2023

    1.1K

    Related Concept Videos

    Satellite Stem Cells and Muscular Dystrophy01:21

    Satellite Stem Cells and Muscular Dystrophy

    Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...
    1.9K
    Abnormal Proliferation02:23

    Abnormal Proliferation

    Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
    4.5K
    Bone Marrow Sampling and Transplants01:22

    Bone Marrow Sampling and Transplants

    Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
    The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
    312
    Differentiation of Common Myeloid Progenitor Cells01:15

    Differentiation of Common Myeloid Progenitor Cells

    Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
    3.2K