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Ferroptosis in eye diseases: a systematic review
Shengsheng Wei1, Jing Li1, Yaohua Zhang1
1Shaanxi Eye Hospital, Xi'an People's Hospital (Xi'an Fourth Hospital), Affiliated People's Hospital of Northwest University, Xi'an, China.
Ferroptosis, an iron-dependent cell death, is implicated in eye disorders. Understanding its mechanisms offers potential therapeutic targets for conditions like age-related macular degeneration.
Area of Science:
- Biochemistry
- Cell Biology
- Ophthalmology
Background:
- Ferroptosis is a distinct form of regulated cell death characterized by lipid peroxidation and iron accumulation.
- It plays a role in various diseases, including neurodegeneration and ischemia-reperfusion injury.
- Research on ferroptosis in ophthalmology is limited, primarily focusing on retinal diseases.
Conclusions:
- Ferroptotic cell death represents a novel area of investigation for eye diseases.
- Targeting ferroptosis pathways could offer new therapeutic strategies for treating ocular disorders.
- Further research is needed to fully elucidate the role of ferroptosis in ophthalmology.
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