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A Double Humanized BLT-mice Model Featuring a Stable Human-Like Gut Microbiome and Human Immune System
Published on: August 30, 2019
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Atypical gut microbiota composition in a mouse model of developmental stuttering
Sayan Nanda1, Bryan Lamot2, Nicole Guarino3
1Department of Communication Sciences and Disorders, University of Delaware, Newark, DE, 19716, USA. snanda@udel.edu.
Scientific Reports
|October 8, 2024
Summary
Developmental stuttering may be linked to gut bacteria changes. Gnptab mutant mice, a model for stuttering, showed distinct gut microbes, including increased Akkermansia, suggesting a new research avenue.
Area of Science:
- Neuroscience
- Microbiology
- Genetics
Background:
- Developmental stuttering is a neurodevelopmental disorder affecting speech fluency.
- Genetic mutations, particularly in lysosomal enzyme trafficking genes like Gnptab, are implicated.
- Gut microbiota's role in neurological disorders is increasingly recognized.
Purpose of the Study:
- To investigate the gut microbiota composition in Gnptab mutant mice, a model for developmental stuttering.
- To identify specific microbial alterations and associated metabolic pathways in the context of stuttering.
Main Methods:
- Comparison of gut microbiota profiles between Gnptab mutant mice and wildtype controls using microbiome analysis.
- Analysis of predicted metabolic pathway alterations based on microbial composition.
Main Results:
- Gnptab mutant mice exhibited a distinct gut microbiota profile compared to wildtype controls.
- A significant increase in the relative abundance of Akkermansia was observed in mutant mice.
- Predicted alterations in metabolic pathways, including short-chain fatty acid and lipopolysaccharide synthesis, were identified.
Conclusions:
- This study reveals a potential link between developmental stuttering and gut microbiota alterations.
- The findings suggest that changes in gut bacteria, such as increased Akkermansia, may influence stuttering.
- This research opens new avenues for understanding and potentially treating developmental stuttering through microbiota modulation.
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