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The O-GlcNAc Database now features 20,000 proteins across 48 species, enhancing its scope. This updated resource offers new tools and data for O-GlcNAc biology research.

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Proteomics

Background:

  • O-GlcNAc is a dynamic post-translational modification on serine/threonine residues of nucleocytoplasmic proteins.
  • The O-GlcNAc Database (OSB) is a widely-used resource cataloging O-GlcNAcylated proteins, with hundreds of monthly users.

Purpose of the Study:

  • To present an updated and expanded O-GlcNAc Database with enhanced features and broader scope.
  • To incorporate community feedback for improved usability and data integration.

Main Methods:

  • Expanded database content to include nearly 20,000 O-GlcNAcylated proteins and 48 species.
  • Implemented new features: protein viewer mode, subcellular localization information, and an O-GlcNAc score.
  • Integrated CytOVS tool for evaluating and sorting O-GlcNAcome datasets from MS experiments.

Main Results:

  • The database has grown substantially in data volume and species coverage.
  • New features enhance data visualization, analysis, and interpretation of O-GlcNAc modifications.
  • Improved resource facilitates research in O-GlcNAc biology.

Conclusions:

  • The updated O-GlcNAc Database is a significantly advanced and comprehensive resource for the scientific community.
  • Enhanced features and expanded data provide greater utility for researchers studying O-GlcNAc biology.