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Related Concept Videos

Transcription01:10

Transcription

156.4K
Overview
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
156.4K
Transcription Attenuation in Prokaryotes02:42

Transcription Attenuation in Prokaryotes

18.5K
Transcriptional attenuation occurs when RNA transcription is prematurely terminated due to the formation of a terminator mRNA hairpin structure.  Bacteria use these hairpins to regulate the transcription process and control the synthesis of several amino acids including histidine, lysine, threonine, and phenylalanine. Transcription attenuation takes place in the non-coding regions of mRNA.
There are several different mechanisms used to attenuate transcription. In ribosome mediated...
18.5K
Transcription Factors02:16

Transcription Factors

82.7K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
82.7K
Master Transcription Regulators02:23

Master Transcription Regulators

7.8K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
7.8K
Eukaryotic Transcription Inhibitors01:52

Eukaryotic Transcription Inhibitors

11.0K
Certain biochemical processes, such as embryonic development and cell growth regulation, depend on the repression of specific genes. DNA binding proteins known as eukaryotic transcription inhibitors regulate the repression of gene expression in eukaryotes. The presence of these inhibitors at the required location and time in the cell is triggered by the presence of hormones and additional signals from other cells.
Eukaryotic transcription inhibitors usually contain two distinct domains, a...
11.0K
Eukaryotic Transcription Activators02:42

Eukaryotic Transcription Activators

12.8K
Transcription activators are proteins that promote the transcription of genes from DNA to RNA. In most cases, these proteins contain two separate domains ‒ a domain that binds to DNA and a domain for activating transcription; however, in some cases, a single domain is responsible for both binding and activation of transcription, as seen in the glucocorticoid receptor and MyoD.
The binding domains are capable of recognizing and interacting with regulatory sequences on the DNA. These...
12.8K

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Related Experiment Video

Updated: Feb 4, 2026

Modeling Age-Associated Neurodegenerative Diseases in Caenorhabditis elegans
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Modeling Age-Associated Neurodegenerative Diseases in Caenorhabditis elegans

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Transcript-Level Modulation of O-GlcNAc Transferase for Aging-Related Neurodegenerative Diseases.

Florian Malard1,2

  • 1Univ. Bordeaux, CNRS, INSERM, ARNA, UMR 5320, U1212, Bordeaux, France.

Chembiochem : a European Journal of Chemical Biology
|February 2, 2026
PubMed
Summary

Targeting O-GlcNAc Transferase (OGT) gene expression offers a new therapeutic strategy for neurodegenerative diseases. Enhancing OGT mRNA splicing and export can restore protein homeostasis and combat conditions like Alzheimer

Keywords:
O‐GlcNAc transferaseO‐GlcNAcylationRNA therapeuticsalternative splicingantisense oligonucleotideneurodegenerative diseases

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Area of Science:

  • Biochemistry
  • Neuroscience
  • Molecular Biology

Background:

  • O-GlcNAc Transferase (OGT) regulates over 8000 proteins via O-GlcNAcylation.
  • Reduced O-GlcNAc levels are linked to neurodegenerative diseases like Alzheimer's and Parkinson's.
  • Current therapies target O-GlcNAcase (OGA) inhibition, but OGT regulation is a promising alternative.

Purpose of the Study:

  • To explore transcript-level regulation of OGT as a therapeutic target.
  • To investigate intron detention and decoy exon mechanisms in OGT pre-mRNA splicing.
  • To propose novel strategies for enhancing OGT expression.

Main Methods:

  • Analysis of intron detention and decoy exon-mediated splicing repression.
  • Proposal of antisense oligonucleotides (ASOs) and selective splicing factor degraders.
  • Focus on promoting productive splicing and nuclear export of OGT mRNA.

Main Results:

  • Identified splicing repression mechanisms limiting OGT pre-mRNA maturation.
  • Proposed therapeutic strategies to enhance OGT expression.
  • Demonstrated potential for restoring proteostasis and neuroprotection.

Conclusions:

  • Transcript-level regulation of OGT presents a novel therapeutic avenue for neurodegenerative diseases.
  • Enhancing OGT expression via splicing modulation can restore proteostasis.
  • This approach offers a promising strategy independent of O-GlcNAc feedback loops.