Trends of Copper Homeostasis in Neoplasms: A Systemic Bibliometric from 2013 to 2023

Copper dysregulation is pivotal in tumorigenesis. This study aimed to elucidate the knowledge framework of copper homeostasis within neoplasms utilizing bibliometric analysis. Publications about copper homeostasis in neoplasms from 2013 to 2023 were retrieved from the Web of Science Core Collection and PubMed databases. The bibliometric analysis was conducted using the RStudio, the CiteSpace software, the VOSviewer software, and a bibliometric analysis platform. A total of 1701 articles were indexed from 73 countries and regions. China has emerged as the leading country with a publication proportion of 32.45%, followed by the USA (10.35%) and India (8.41%). Significant collaborations have been conducted among Chinese academic institutions. The Journal of Inorganic Biochemistry emerged as the most prominent journal. Among the 4841 keywords extracted from 671 journals, concepts of cell death, positron emission tomography, and tumor microenvironment emerged as the most significant hotspots. This bibliometric study reviewed significant academic development and synthesized research trends on copper homeostasis in neoplasms, providing a valuable reference for scholars.