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Updated: Jun 11, 2025
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An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney
Published on: November 1, 2018
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Short- and long-term outcomes in critically ill patients with primary glomerular disease: a case‒control study
Nicoli Ferri Revoredo Coutinho1, Alexandre Braga Libório2
1Medical Sciences Postgraduate Program, Universidade de Fortaleza- UNIFOR, Fortaleza, Ceará, Brazil.
BMC Nephrology
|October 8, 2024
Summary
Critically ill patients with primary glomerulopathy have high long-term mortality despite similar hospital survival. Serum albumin and comorbidities predict long-term outcomes, underscoring the need for focused risk assessment in intensive care unit (ICU) settings.
Area of Science:
- Nephrology
- Critical Care Medicine
- Epidemiology
Background:
- Primary glomerulopathies represent a significant health burden with substantial morbidity and mortality.
- Limited data exists on the intensive care unit (ICU) outcomes for critically ill patients with primary glomerulopathy.
Purpose of the Study:
- To investigate the characteristics, predictors of mortality, and outcomes of critically ill patients with primary glomerulopathy admitted to the ICU.
- To compare hospital and long-term mortality between patients with primary glomerulopathy and a matched control group.
Main Methods:
- A case-control study utilizing the Medical Information Mart for Intensive Care IV (MIMIC-IV) database.
- Inclusion of 307 patients with primary glomerulopathy from 50,920 ICU patients.
- Logistic regression and mediation analysis to identify mortality predictors.
Main Results:
- Infectious and cardiovascular causes, particularly sepsis, were primary ICU admission reasons.
- Hospital mortality was comparable to controls; however, three-year long-term mortality was 29.0%.
- Reduced urine output and low serum albumin predicted hospital mortality; low serum albumin and high Charlson Comorbidity Index predicted long-term mortality. Acute kidney injury was not significantly associated with mortality.
Conclusions:
- Critically ill patients with primary glomerulopathy have distinct ICU characteristics and high long-term mortality.
- Serum albumin and Charlson Comorbidity Index are key predictors of long-term mortality, necessitating comprehensive risk assessment.
- Further research is needed to elucidate the relationship between acute kidney injury and mortality in this cohort.
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