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Zinc-based Polyoxometalate Nanozyme Functionalized Hydrogels for optimizing the Hyperglycemic-Immune Microenvironment
Chaoyu Pu1,2, Yong Wang1, Honglin Xiang1
1Department of Orthopedics, Laboratory of Biological Tissue Engineering and Digital Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, P.R. China.
Journal of Nanobiotechnology
|October 8, 2024
Summary
This study presents a novel hydrogel regulator (AHAMA/CS-GOx@Zn-POM) that effectively treats diabetic wounds by controlling the hyperglycemic and immune microenvironments. The regulator promotes wound healing through enhanced angiogenesis and collagen regeneration.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Nanotechnology
Background:
- Diabetic wounds exhibit hyperglycemia-induced cytotoxicity and impaired immune cell function, hindering healing.
- Effective diabetic wound treatment requires regulating the hyperglycemic and immune microenvironments.
Purpose of the Study:
- To develop a nanozymatic regenerative microenvironmental regulator for diabetic wound repair.
- To investigate the integrated control of hyperglycemic and immune factors for enhanced wound healing.
Main Methods:
- Development of AHAMA/CS-GOx@Zn-POM: a hydrogel incorporating glucose oxidase (GOx) and a zinc-based nanozyme (Zn-POM).
- In vitro assessment of GOx and Zn-POM activities in managing hyperglycemia and oxidative stress.
- In vivo evaluation in a rat diabetic wound model to assess neovascularization and collagen deposition.
Main Results:
- GOx catalyzed glucose to gluconic acid, mitigating hyperglycemia; Zn-POM scavenged reactive oxygen species and H₂O₂.
- Zn-POM reprogrammed M1 macrophages to M2 phenotype by inhibiting MAPK/IL-17 signaling, reducing inflammation.
- The regulator significantly enhanced angiogenesis and collagen deposition, accelerating diabetic wound healing in rats.
Conclusions:
- AHAMA/CS-GOx@Zn-POM effectively converts pathological microenvironments to regenerative ones in diabetic wounds.
- Integrated control of hyperglycemic-immune microenvironments offers a novel therapeutic strategy for diabetic wound treatment.
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