Related Experiment Video

Updated: Jun 11, 2025

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
00:04

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

10.6K

Parenteral nutrition customization in pediatrics: A descriptive cohort study

Jéssica Lavanholi Pinho1, Renata Germano Borges de Oliveira Nascimento Freitas1, Roberto Jose Negrão Nogueira2

  • 1Department of Pediatrics of the School of Medical Science, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil.

JPEN. Journal of Parenteral and Enteral Nutrition
|October 9, 2024
PubMed

Insights

Customizing parenteral nutrition (PN) is crucial for pediatric intensive care and malnourished patients, often due to energy-protein needs and mineral disturbances. This highlights the need for specialized teams and systems for effective PN delivery.

Area of Science:

  • Pediatric Nutrition
  • Clinical Nutrition
  • Medical Nutrition Therapy

Background:

  • Parenteral nutrition (PN) is a complex therapy requiring careful individualization, especially in vulnerable pediatric populations.
  • Standard PN formulations may not meet the unique metabolic and clinical needs of hospitalized children.
  • Understanding the specific reasons for PN customization is vital for optimizing patient outcomes and resource allocation.

Purpose of the Study:

  • To analyze the primary indications for customizing parenteral nutrition (PN) in pediatric patients admitted to a quaternary care hospital.
  • To identify the frequency and timing of PN customization requirements in this population.

Main Methods:

  • A descriptive cohort study was conducted involving 264 hospitalized pediatric patients receiving PN.
  • Data collected included anthropometric, biochemical, and hospitalization details from patient records.
  • Customization reasons were defined as conditions precluding standard adult/teenager PN, including renal/liver failure, energy-protein needs, and mineral/triglyceride abnormalities.

Main Results:

  • The majority of patients (87.9%) required customized PN within 48 hours, primarily for energy-protein adequacy.
  • Mineral disturbances became a significant reason for further PN individualization within the first 4 days.
  • High rates of customization were observed throughout the first week of PN therapy (97.4% at 48h, 96.2% at day 4, 90.1% at day 7).

Conclusions:

  • Customized PN is essential for pediatric patients, particularly those who are younger, malnourished, or in intensive care.
  • The findings underscore the importance of a Nutritional Multidisciplinary Therapy Team.
  • Implementation of a dedicated electronic system for PN prescription is recommended to enhance safety and efficiency.
Abstract

Keywords:
childcritical carenutrition supportnutrition therapy

More Related Videos

Author Spotlight: Exploring Venous Waveforms in Porcine Models to Tackle Volume Overload in Medicine06:09

Author Spotlight: Exploring Venous Waveforms in Porcine Models to Tackle Volume Overload in Medicine

Published on: January 12, 2024

531
Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers09:36

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers

Published on: July 28, 2022

2.2K

Related Concept Videos

Parentral Nutrition: Centeral and Peripheral Parental Nutrition01:27

Parentral Nutrition: Centeral and Peripheral Parental Nutrition

Parenteral Nutrition (PN) delivers essential nutrients directly into the bloodstream, bypassing the digestive system. It is commonly used for individuals with severe digestive disorders or conditions that prevent normal nutrient absorption.
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
105
Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding01:15

Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding

Enteral nutrition encompasses various methods of delivering nutrition directly to the gastrointestinal (GI) tract, bypassing traditional oral intake. It is particularly beneficial for patients who cannot eat by mouth but have a functioning digestive system. Key methods include nasointestinal feeding, gastrostomy, and jejunostomy, each suited to different clinical scenarios based on the patient's needs and condition.
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube...
83
Enteral Nutrition I: Orogastric and Nasogastric Feeding01:26

Enteral Nutrition I: Orogastric and Nasogastric Feeding

Enteral nutrition delivers nutrients directly to the stomach or small intestine through a tube. This method is appropriate for patients who cannot eat but still have a functioning digestive system. It is also beneficial for individuals with swallowing difficulties, anorexia, malabsorption, or those who have undergone gastrointestinal (GI) surgery.
Orogastric (OG) and nasogastric (NG) feeding are two standard methods used for enteral nutrition. Enteral nutrition is often preferred over...
212
Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
438
Routes of Drug Administration: Parenteral01:25

Routes of Drug Administration: Parenteral

The administration of drugs via parenteral routes allows for direct drug introduction into the systemic circulation, resulting in high bioavailability because the medication bypasses the harsh conditions of the gastrointestinal tract and hepatic metabolism.
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
1.9K
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
385